Acebrophylline - Antiasthmatics-(May 2008)Drug Name:
Acebrophylline - Antiasthmatics-(May 2008)
List Of Brands:
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Plasma concentration of acebrophylline may be increased by concurrent admin. of erythromycin, cephalexin, oxytetracycline, oligomycin, lincomycin, cimetidine, clindamycin, allopurinol, quinolones, anticoagulants etc.
If concurent use of acetobrophylline is essential the dose of acebrophylline should be reduced.
Concomittant use of acetobrophylline and furosemide can potentiate diuresis.
Concomittant of use of acetobrophylline and reserpine can cause tachycardia
Acetobrophylline plasma conc. may be decreased in patients by co-administration with drugs like phenytoin and barbiturates and in patients who smoke.
Advisable not to use acebrophylline with any other theophylline derivative, ambroxol derivative or central nervous stimulants.
Caution is adviced when acetobrophylline is used with ehpedrine, symapthominietics and other bronchodilator.
Mild gastrointestinal discomfort stomach/abdominal distention vomiting abdominal pain
diarrrhea constipation heartburn loss of appetite oespophageal bleeding rashes urticaria
itching drowsiness difficulty in breathing leucocytosis and nasal
Rarely reported numbness in arm insomnia tachycardia fatigue hypertension albuminuria
glycosuria hypotension hyperglycemia
Hypersentivity to ambroxol, acebromophylline, thophylline or any other xanthine derivative
Acute myocardial infarction
Hypotension, hemodynamic instability and arrhythmias
renal disease liver disorder
Dosages/ Overdosage Etc:
Mechanism of action Acebrophylline is an anti-inflammatory and air way mucus regulator it contains ambroxol and theophylline -7 acetic acid, the former facilitates the biosynthesis of pulmonary surfactant while later raises blood levels of amboxol therby stimulating surfactant production The improvement in ciliary clearance results by reduction in the viscosity and adhesivity of mucus.
Ambroxol and theophylline -7 acetic acid reach optimal concentration and very low levels in the intestine respy. Ambroxol reaches its peak concentration in 2 hours and theophylline -7 acetic acid after 1 hour
Interaction with Food:
Pregnancy and lactation: