Plasma concentration of acebrophylline may be increased by concurrent admin. of erythromycin, cephalexin, oxytetracycline, oligomycin, lincomycin, cimetidine, clindamycin, allopurinol, quinolones, anticoagulants etc.

If concurent use of acetobrophylline is essential the dose of acebrophylline should be reduced.

Concomittant use of acetobrophylline and furosemide can potentiate diuresis.

Concomittant of use of acetobrophylline and reserpine can cause tachycardia

Acetobrophylline plasma conc. may be decreased in patients by co-administration with drugs like phenytoin and barbiturates and in patients who smoke.

Advisable not to use acebrophylline with any other theophylline derivative, ambroxol derivative or central nervous stimulants.

Caution is adviced when acetobrophylline is used with ehpedrine, symapthominietics and other bronchodilator.

Mild gastrointestinal discomfort stomach/abdominal distention vomiting abdominal pain

diarrrhea constipation heartburn loss of appetite oespophageal bleeding rashes urticaria

itching drowsiness difficulty in breathing leucocytosis and nasal

Rarely reported numbness in arm insomnia tachycardia fatigue hypertension albuminuria

glycosuria hypotension hyperglycemia

Hypersentivity to ambroxol, acebromophylline, thophylline or any other xanthine derivative

Acute myocardial infarction

Hypotension, hemodynamic instability and arrhythmias

renal disease liver disorder

Pharmacology

Mechanism of action Acebrophylline is an anti-inflammatory and air way mucus regulator it contains ambroxol and theophylline -7 acetic acid, the former facilitates the biosynthesis of pulmonary surfactant while later raises blood levels of amboxol therby stimulating surfactant production The improvement in ciliary clearance results by reduction in the viscosity and adhesivity of mucus.

Pharmacokinetics

Ambroxol and theophylline -7 acetic acid reach optimal concentration and very low levels in the intestine respy. Ambroxol reaches its peak concentration in 2 hours and theophylline -7 acetic acid after 1 hour

Not reported

Not reported