Antipsychotic agents group -

     Include- Chlorpromazine, Promazine, Thioflupromazine,Mesoridazine, Thioridazine ,Acetophenazine  Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine,  Chlorprothixene, Thiothixene                 Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine ,   Ziprasidone, Paliperidone, Risperidone, Aripiprazole    

 
Refer Chlorpromazine
 

Schizophrenia

Antipsychotic agents group -
     Include- Chlorpromazine, Promazine, Thioflupromazine,Mesoridazine, Thioridazine ,Acetophenazine
                    Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine,  Chlorprothixene, Thiothixene
                    Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine ,
                    Ziprasidone, Paliperidone, Risperidone, Aripiprazole      

Refer Chlorpromazine
 

Antipsychotic agents group -
     Include- Chlorpromazine, Promazine, Thioflupromazine,Mesoridazine, Thioridazine ,Acetophenazine
                    Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine,  Chlorprothixene, Thiothixene
                    Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine ,
                    Ziprasidone, Paliperidone, Risperidone, Aripiprazole  

    
Refer Chlorpromazine
 

Antipsychotic agents group -
     Include- Chlorpromazine, Promazine, Thioflupromazine,Mesoridazine, Thioridazine ,Acetophenazine
                    Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine,  Chlorprothixene, Thiothixene
                    Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine ,
                    Ziprasidone, Paliperidone, Risperidone, Aripiprazole      
Refer Chlorpromazine
 

Indications:
Schizophrenia

Dosage:
Initial- 50 to 75mg/day, increased to 100mg/day in 3 or 4 days. Severe cases may need
225mg/day

Maintenance- Mild- 5 to 15mg 3 or 4 times daily; Moderate - 10 to 25mg 3 or 4 times daily
Severe- 225mg/day

 

MOLIDONE - ANTIPSYCHOTIC AGENTS-

1.Allergies-
  Tell your doctor if you have ever had any unusual or allergic reaction to Molidone, phenothiazines,  haloperidol,
  or loxapine.  Also tell your doctor if youare allergic to any other substances, such as foods, presrvatives or dyes.
   
2.Pregnancy - haloperidol have shown reduced fertility, delayed delivery, cleft palate, and an increase in number
   ofstillbirths and newborn deaths.

3. Breast feeding-  not recommended  

4 Children - side effects especially muscle spasms of the neck and back and twisting movements of the body,
   trembling fingers and hands and inabilitry to move the eyes are more likely to occur

5. Elderly- constipation,dizziness, or fainting ,drowsiness,dryness of the mouth , trembling of the hands and fingers
    and symptoms of tardive dyskinesia  or other uncontrolled movements of the mouth of the mouth, tongue, jaw
    are sepecially likely to occur in elderly.  

10. Other medicines -

    Let your doctor know what other medicines you are taking, so that he can advice you accordingly.
   
    Amoxapine or
    Metclopromide or
    Metyrosine or
    other antipsychotic medicines or
    Pemoline or0
    Pimozide or
    Promethazine or
    Rauwoulfia alkaloids or
    Trimeprazine - taking these medicines with haloperidol may increae the frequency and severity of certain
    side effects.     
    
    CNS depresants- that cause drowsiness or
    Tricyclic antideprsants - taking these mediociones togetherr with haloperidol may result in increased CNS
    and other depressant efects,and increase chance of low blood pressure -hypotension

    Ephinephrine - severe low blood pressure or irregular heartbeat may occur

    Levodopa - haloperidol may interfere with the effects of tis medicine
    Lithium- although lithium and haloperidol are sometime used together their use must be closely monitored
    by your doctor who may change the amount of medicine you need to take
     
10. Other medical problems -

   Tell your doctor if you have any other medical problems especially -

    Alcohol abuse - risk of herat stroke may be increased
    Difficult urination or
    Glaucoma or
    Heart or blood vessel disease or
    Lung disease or
    Parkinsons disease -haloperidol may make the condition worse
    Epilepsy -the risk of seizures may be increased
    Kidney disease -higher blood levels of haloperidol may occur increasing the chance ofside effects

     Overactive thyroid- serious unwanted effects may occur

11. Missed dose -
    If you miss a dose of this medicine, take it as soon as possible. however, if it is almost time
      for the next dose, skip the missed dose. Do not double doses.

12. Storage -
     Keep out of reach of children. Store away from heat or direct sunlight. Do not store
      the capsule in bathroom, near the kitchen sink, or in other damp places.

13. Outdated medicines -
   Do not keep outdated medicine or medicine no longer needed. Be sure that any
     discarded medicine is out of reach of children.


 

Antipsychotic agents group -
     Include- Chlorpromazine, Promazine, Thioflupromazine,Mesoridazine, Thioridazine ,Acetophenazine
                    Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine,  Chlorprothixene, Thiothixene
                    Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine ,
                    Ziprasidone, Paliperidone, Risperidone, Aripiprazole      
Refer Chlorpromazine

Pharmacology:
Molidone  is structurally unrelated to the phenothiazines, butyrophenones or thioxanthenes, but it
resembles the pierazine phenothiazines in its clinical action.

Pharmacokinetics:
Molidone is rapidly absorbed and metabolised. Unmetabolised drug  reaches peak blood levels
at 1.5 hours.