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Updated On: 18-11-2024

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Flupentixol - @ Antidepressant

Drug Name:
Flupentixol - @ Antidepressant

List Of Brands:

FLUANXOL
SPENZO
FLUPEN

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Potentiates CNS effect of alcohol.

Blocks antihypertensive effect of guanethedine.

Inhibits metabolism of tricyclic antidepresants and vice-versa.

Reduced efficacy of levodopa.

Increases adverse extrapyrimidal symptoms with dopamine antagonist (metoclopamide and prochlorperazine).

Indication:

Depression

Adverse Reaction:

Neuroleptic malignant syndrome, Hyperthermia,hypertoxicity of skeletal muscles,

Unconsciousness and ANS instability, Rigidity,tremors,reslessness,

Tardive,dryskinesia, insomnia, Dryness of mouth, weight gain,

Sexual dysfunction, breast engorgement,

Galactorrhoea and Menstrual disturbances.

Contra-Indications:

Extremely excitable & overactive patients.

Acute alcohol, barbiturate & oolate poisioning.

Pregnancy,lactation, Coma, Parkinson,s disease.

Special precautions:

Monitor patients on long term therapy carefully.

Caution in patients with convulsive disorders or advanced hepatic,renal or cardiovascular disease. Do not operate machinery or drive vehicles.

Neuroleptics with sedative effect,if any being used by the patient,should be withdrawn gradually.

Dosages/ Overdosage Etc:

Indication

Depression

Dosage-

Intially 1mg (elderly 0.5mg ) in the morning, increased after 1 week to 2mg ( elderly 1mg) to be divided in 2 portions , second dose not after 4pm

Discontinue if no response after 1 week at maximum dosage.

Not recommended for children

Patient Information:

1.Do not stop taking this medicine without checking with your doctor.

2. Avoid alcohol and other CNS depressant drugs while taking this medicine.

3. Tell your doctor or dentist that you are taking this medicine before

undergoing any kind of surgery.

Ref - USP PDI Vol II 17th Edition (1997)

THIOXANTHENES - SYSTEMIC

Applicable to

CHLORPROTHIXENE

FLUPENTHIXOL

THIOTHIXENE

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

Thioxanthine. Also tell your healthcare care professional if you are allergic

to any other substances such as foods. preservatives or dyes.

2.Pregnancy-

Studies have not been done in pregnant women. Although ,animal studies

have not shown that thioxanthene cause birth defects, the studies have

shown that these medicines cause a decrease in fertility and fewer

successive pregnancies.

3. Breast-feeding-

It is not known whether thioxanthenes pass into breast milk. However,

similar medicines for nervous, mental, or emotional conditions do pass

into breast milk and may cause drowsiness and increase the risk of

other problems in the nursing baby. Be sure that you have discussed this

with your doctor.

4.Children-

Certain side effects such as muscle spasm of the face, the neck and back,

tie-like or twitching movements inability to move the eyes, twisting of the

body, or weakness of the arm or thelegs are more likely to occur in the

children who are more sensitive than the adults.

5.Older adults-

Constipation, dizziness, or fainting, drowsiness, dryness of the mouth,

trembling of the hands and fingers, and symptoms of tardive dyskinesia,

( such as rapid, worm-like movement of the tongue or any other

uncontrolled movements of the mouth or the tongue, or jaw and/or

arms and legs) are especially likely to occur in elderly patients.

6. Other medicines-

Tell your doctor if you are using any other medicines you are taking

which may interact and produce harmful effects.

7. Other medical problems-

The presence of other medical problems may affect the use of thioxanthenes.

Make sure you tell your doctor if you have any other medical problems

which may produce unwanted effects.

Interaction with Food:

Reports not available.

Pregnancy and lactation:

Pregnancy:

Studies have not done on pregnant women. Animal studies have reported some adverse effects on fetus.

Lactation:

Not known whether Flupenthixol pass into breast milk, although similar medicines do pass into breast milk and cause drowsiness and increase risk of other problems to the nursing baby.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.