Approved by FDA on June 7, 1995
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Sevoflurene Inhaltion 09-07-1996
Induction and maintenance of general anesthesia in all types
of procedures and patients
Ref - USP PDI Vol II 17th Edition (1997)
SEVOFLURANE - INHALTION- SYSTEMIC
Tell your doctor if you have ever had any unusual or allergic reaction to
an anesthetic. Also tell your healthcare care professional if you are allergic
to any other substances such as foods. preservatives or dyes.
Sevoflurane has not been studied in pregnant women.
It is not known whether sevoflurane passes into breast milk. Mothers who
are taking this medicine and who wish to breast feed should discuss this
with their doctor.
Sevoflurane has been tested in children. Sevoflurane may cause children
to become agitated when it is used to start anesthesia when they are wake.
Also children receiving sevoflurane during surgery may become agitated
as they awaken after surgery.
Sevoflurane has been tested and does not cause different side effects in older
people than younger adults.
6. Other medicines-
Tell your doctor if you are taking any other prescription or non-prescription
(Over-the counter) OTC medicine including the following-
Polymycin - use of these medicines with sevoflurane may increase the
effect of sevoflurane
7. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
Disease than cause muscle weakness such as familial periodic analysis,
muscular atropy, myasthenia gravis or myasthenic syndrome- weakness
may be increased
Head injury- sevoflurane may make the condition worse
Kidney disease - sevoflurane may make this condition worse
Liver disease- the effects of sevoflurane may be increased
Malignant hyperthermia, during or shortly after receiving anesthetic
- this side effect may occur.
Portwine stain- sevoflurane may interfere with laser effect treatment
to remove portwine stain