Drug Interaction:
NSAIDs include-
Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams- Piroxicam
Refer- Ibuprofen
Potentiates methorexate, lithium, protein bound drugs Increased risk of GI Bleed with aspirin, corticosteroids, smoking, anticoagulants May antagonise or increase risk of renal failure with ACE inhibitors, diuretics Monitor oral anticoagulants, antihypertensives
Indication:
LIST OF DRUGS DURING 2007
Sr.No- 154
Name of the Drug- Oxaprozine Tablet 600mg
Pharmacological Classification- For relief of signs and symptoms of
osteoporosis, rheumatoid arthiritis
Date of Approval- 30-10-07
Approved by U.S.FDA on 30-12-2007 (Ref- FDA approved List- 2007)
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing (Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Oxaprozine tablet 600mg 30-10-2007
For the relief of signs and symptoms of osteoarthiritis, Rheumatoid
Arthiritis
Rheumatoid arthiritis Osteoarthiritis
NSAIDs include-
Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams-
Piroxicam Refer- Ibuprofen
Adverse Reaction:
GI upset, CNS effects, tinnitus, blurrred vision, Dysuria, oedema, GI ulcer bleed, photosensitivity Blood dyscrasias, Renal or hepatic dysfunction Rash ( discontinue if occurs ) Risk of cardiovascular events
Contra-Indications:
Aspirin allergy Coronary artery bypass graft surgery Advanced renal disease Third trimester of pregnancy Lactation
Special Precaution-
Renal or hepatic dysfunction Discontinue if renal or hepatic disease develops History of GI bleed/ulcer Bleeding disorders Monitor CBC, hepatic and renal function in chronic use and for GI bleed ulcer Heart failure Asthma Hypertension Alcoholism Elderly, debilitated, dehydrated Pregnancy Labour
Dosages/ Overdosage Etc:
Indication-
Rheumatoid arthiritis Osteoarthiritis Rheumatoid arthiritis
Dosage-
- 1.2g once daily Max. 1.8g or 26mg/kg daily, whichever is less, in divided doses Lower body weight, milder disease or on dialysis-initially 600mg once daily, max 1.2g daily
Patient Information:
NSAIDs include-
Propionic acid- Fenoprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Naproxen, Naproxen Sodium, Oxaprozin Acetic acids- Diclofenac sodium, Etodolac, Indomethicin, Ketorolac, Nabumetone, Sulindac, Tolmetin Fenamates (anthralic acids) - Meclofenamate, Mefenamic acxid Oxicams- Piroxicam Refer- Ibuprofen
Pregnancy and lactation:
Contraindicated for use during pregnancy and lactation.
Observe caution if required to be used
Manufacturer Details