RAPAFLO *
Manufacturer Details
ABBOTT INC
Abbott Laboratories
Pharmacetical Division
Compositions:
Silodosin 4mg/ 8mg tabs,
|
Strength
|
Rate
|
Packing Style
|
|
4mg
|
0.00
|
Tab
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8mg
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0.00
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Tab
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List of Related Indications:
- Benign prostatic hyperplasia
List Of Drugs:
- Silodosin - @ Antiadrenergic Agents - Periph Acting- (June 2011)
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl
Refer - Prazosin
Indication:
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Silodosin Capsules 23-06-2011
2mg/4mg/8mg
For the treatment of Signs nd symptoms of Benign Prostratic Hyperplasia
(BPH) in adults only
Benign Prostatic Hyperplasia
Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl
Refer - Prazosin
Contra-Indications:
Renal function impairment- Silodosin is contraindicated in patients with severe renal impairment ( creatinine clearance CrCl less than 30mL/min)
In patients with moderate renal impairment CrCl 30 to 50mL/min the dosage should be reduced to 4mg once daily taken with a meal.
No dosage adjustment is required in patients with renal impairment CrCl 50 to 80mL/min
Hepatic function impairment - silodosin has not been studied in patients with severe hepatic impairment ( Child Pugh score of 10 or greater and therefore contraindicated No dosage adjustment is needed in patients with mild modera hepatic impairment.
Dosages/ Overdosage Etc:
Indication-
Benign Prostatic Hyperplasia
Dosage-
8mg orally once daily with meals
Renal function impairment- Silodosin is contraindicated in patients with severe renal impairment ( creatinine clearance CrCl less than 30mL/min) In patients with moderate renal impairment CrCl 30 to 50mL/min the dosage should be reduced to 4mg once daily taken with a meal.
No dosage adjustment is required in patients with renal impairment CrCl 50 to 80mL/min
Hepatic function impairment - silodosin has not been studied in patients with severe hepatic impairment ( Child Pugh score of 10 or greater and therefore contraindicated
No dosage adjustment is needed in patients with mild modera hepatic impairment.
Patient Information:
Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl
Refer - Prazosin
Pharmacology/ Pharmacokinetics:
Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel s
Refer - Prazosin
Interaction with Food:
Can be taken with meals
