Adverse Reaction:
Haematologic- dose related bone marrow depression, leukopenia, thrombocytopenia anemia
GI- nausea, vomiting, or diarrhea of varying severity ( dose related )
Dermatologic- pruritus, dermatitis, hair loss, ( may or may not be dose related )
CNS- nervousness, irritability, depression ( may or may be dose related )
Miscellaneous- hepatotoxicity (rare ) amenorrhoea, azoosperma
Patient Information:
1. May cause nausea, vomiting, or diarrhea, notify physician if these effects persist
2. Notify doctor of unusal bleeding or bruising , fever, chills, sore throat, cough,
shortness in breath, seizures, lack of menstrual flow, unusual lumps, or masses,
flank, joint or stomach pain, sores in mouth or on lips, yellow discoloration
of skin/eyes
Ref - USP PDI Vol II 17th Edition (1997)
URACIL MUSTARD - SYSTEMIC
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
Uracil mustard.
2.Pregnancy-
Tell your doctor if you are pregnant or intend to have children. This medicine
may cause birth defects if either the male or female is taking it at the time of
conception or it is taken during pregnancy. Also many cancer medicines may
cause sterility which could be permanent.
Tell your doctor right away if you think you are pregnant or you become
pregnant while taking this medicine.
3. Breast-feeding-
Tell your doctor if you are breast feeding or if you intend to breast feed during
treatment with this medicine. Breast feeding is not generally recommended
while you are taking it.
4.Children-
Although there is no specific information about the of uracil mustard in children,
it is not expected to cause different side effects or problems than it does in adults.
5.Older adults-
There is no specific information about the use of uracil mustard in the elderly
6. Other medicines-
When you are taking uracil mustard, it is especially important that your doctor
know if you are using any of the following medicines.
Amphotericin or
Antithyroid agents or
Chloramphenicol or
Colchicine or
Flucytosine or
Interferon or
Pilcamycin or
Zidivudine - uracil mustard may increase the concentration of uric acid in the
blood, which these medicines are used to lower
7. Other medical problems-
The presence of other medical problems may affect the use of uracil mustard.
Make sure you tell your doctor if you have any other medical problems
especially-
Chicken pox or
Herpes zoster or
Gout or
Kidney stones - uracil mustard may increase levels of uric acid in the body,
which can cause gout or kidney stones
Infection - uracil mustard can reduce immunity to infection
Kidney disease
Liver disease
Manufacturer Details