List of Related Indications:
- Adenocarcinoma of the breast
- Supfl paplr adencarc of urnbld
- Adenocarcinoma of the ovary
- Intrcav effus-loc/dessm neopls
List Of Drugs:
- Thiotepa @ - (TSPA,TESPA)- Alkylating agent
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Alkylating Agents Include-
Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin
Reduced activity of cytochrom. P-450 leads to inactivation of cyclophosphamide, procarbazine, etoposide, and nitrosoureas Interferes with adsorption of other drugs given orally.
Alkylating Agents Includes- Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin
Bone marrow supression,second malignancy. Bone marrow depression, irrerversible hypoplastic anaemia Headache, dizziness,allergy, impaired fertility, hypersensitivty reaction.
Thrombocytopenia and leucopenia. Ulceration and necrosis on extrvasation,local irritation at site of injection. Intravesical instillation: haemorrhagic cystitis.
Bone marrow depression, acute infections, hypersens.
Special precautions: Severe hepatic renal dysfunction, regular blood counts.
Dosages/ Overdosage Etc:
Indications: Adenocarcinoma of breast, ovary.
Dosage: IV admin - 0.3 to 0.4 mg/kg at 1 to 4 week intervals by rapid administration.. Storage: Store the original powder and the reconstituted solution in refrigerator at 2 to 8C. Reconstituted solution stable when refrigerated.
Thiotepa is a cell cycle nonspecific alkylating agent. Its radiomimetic action is believed to occur through the release of ethylene radicals which disrupt the bonds of desoxyribonulceic acid (RNA) Pharmacokinetics: Urinary excretion of thiotepa and metabolites was 63%.
Interaction with Food:
Pregnancy and lactation:
Antineuoplastic agents include- Amsacrine, carboplastin, cisplantin, crisantaspase, hydroxyurea, dacarbazine, procarbazine. Refer- Hydroxyurea