Reduces absorption of oral digoxin (solid dose). Increases absorption of aspirin, paracetamol and oral diazepam.

Effects antogonised by anticholinergic agents.

Enhances CNS depression by phenothiazine.

Antimuscarinic agents and opioids, antagonise G.I.effects.

Acute nausea and vomiting.

Seen only on I.V.administration.

Dsyarryhthmaias and death in patients with CVS disease or hypokalaemias and patients on cancer chemotherapy.

Seizures,hypotensive crisis in patients with pheochromocytoma.

Drowsiness and extrapyrimidal reactions (lower incidence than metaclopromide), galactrorrhoea, gynaecomastia,

Constipation or diarrhoea, drowsiness, lassitude, skin and itch.

Hypersensitivity, pregnancy,

GI haemorrhage, obstruction and perforation,or after surgery.

Special Precautions:

Pheochromocytoma,children,elderly,renal/hepatic impairment, cardiac arrhythmias and hypokalaemia.

New drug application (NDA)in 1985

Indications:

Acute nausea and vomiting. Dosage: 20 to 40mg 3 to 4 times a day.

Children - 0.3mg/kg 3 to 4 times a day.

Missed dose-

1. If you miss a dose of this medicine, take it as soon as possible.

2. However, if it is almost time for next dose, skip the missed dose and go back to your regular dosing schedule.

3. Do not double doses.

Pharmacology:

Domperidone is chemically unrelated to the butyrophenones,phenothiazines or metoclopramide. Hoever, it shares pharmacolgical activity with these agents. Dompridone is a pheriphral dopamine antagonist, however it does not produce CNS effects. It selectively blocks peripheral dopamine receptors in the gastrointestinal wall, thus enhancing normal syncronized GI peristalsis effect.

Pharmacokinetics:

Peak plasma levels are reached within 30 minutes following IM or oral administration and between 1 to 4 hours after rectal administration. Metabolism: It is metabolised in the liver and eliminated in the urine,primarily in conjugates. Less than 1% appears in urine as unchanged drug.Excretion is complete in 4 days.

Delayed absorption but higher bioavailabilty due to reduced first pass metabolism in gut wall.

Use during pregnancy contraindicated. Observe caution