Drug Interaction:
Drug interactions - summary
Sulphadoxine +
Antifolic drugs eg. methotrexate/Sulfonamides/TMP- SMZ- concurrent pyrimethamine increase the risk of bone marrow suppression . discontinue pyrimethimine if signs of folate defeciency develop
Indication:
Chemophylaxis of malaria
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
Sulfametopyrazine 500mg + May 1978
Pyrimethamine 25mg tablet
Adverse Reaction:
Insomnia, diarrhea, headache, lightheadedness, Dryness of the mouth or throat, fever, malaise, Dermatitis, abnormal skin pigmentation, Depression, seizures, pulmonary eosinophilia. Cardiac rhythm disorders. Anorexia, vomiting, vomting may minimised by giving with meals. Atrophic glossitis
Contra-Indications:
Hypersensitivity. Megaloblastic anemia due to folate defiency.
Dosages/ Overdosage Etc:
Indications:
Chemoprophylaxis of malaria.
Dosage:
Adults and children (more than 10 years old)- 25mg once weekly Children(4 to 10 years old)- 12.5mg once weekly Infants and children(less than 4 years old)- 6.25mg once weekly
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
PYRIDOXINE - ( VITAMIN B6) -Systemic
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
pyridoxine. Also tell your healthcare care professional if you are allergic
to any other substances such as foods. preservatives or dyes.
2.Pregnancy-
It is important that you are receiving enough vitamins when you are pregnant
and that you continue to receive throughout the pregnancy. However,
taking amounts of dietary supplement during pregnancy may cause the infant
to be dependent on pyridoxime.
3. Breast-feeding-
Although it is important that you receive the right amounts of vitamins so that
your baby will also get the vitamins to grow properly, taking large amounts of
dietary supplements may be harmful to the mother and or baby and should
be avoided.
4.Children-
Problems in children have not been reported with intake of normal recmmended
amounts.
5.Older adults-
Problems in older adults have not been reported with normal daily recommended
daily amounts
6. Other medicines-
Tell your doctor if you are using any of the following -
Levodopa - use with pyridoxime may prevent the levodopa from working properly
Pharmacology/ Pharmacokinetics:
Pharmacology:
Pyrimethamine is a folic acid antagonist. Its therapetc action is based on differential requirement between host and parasite for nucleic acid precursors involved in growth as it selectively inhibits dihydrofolate reductase
Pharmacokinetics:
Well absorbed after oral use. Peak plasma concentrations occur in 2 to 6 hrs. Plasma half-life is 4days.
Interaction with Food:
Can be taken with food
Pregnancy and lactation:
Pregnancy:
Co-administration with folinic acid is recommended.
Lactation:
Safety for use is not established. Because of the potential hazards to the nursing infant, decide whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Manufacturer Details