Potentiates CNS depressants including alcohol,barbiturates analgesics,sedatives and neuroleptics. MAOIs,atropine, antidepressants enhance antimuscarinic effect. Masks ototoxicity produced by aminoglycoside antibiotics. Incompitable with aminophylline, hydrocortisones, phenothiazines,and soluble barbiturates.

Refer Chlorpromazine - Antiemetic Antipsychotic agents group - Include- Chlorpromazine, Promazine, Triflupromazine,Mesoridazine, Thioridazine ,Acetophenazine Perphenazine,Prochlorperazine, Fluphenazine, Trifluoperazine, Chlorprothixene, Thiothixene Haloperidol,Pimozide,Molindone,Loxapine,Clozapine ,Olanzapine,Quetiapine , Ziprasidone, Paliperidone, Risperidone, Aripiprazole Refer Chlorpromazine ===========================================================================================

CNS depression,paradoxical CNS stimulation,dryness of mouth, Thickened respiratory secretions, Blurring of vision, Urinary retension,constipation, Bradycardia, followed by tachycardia and arrhythmias. GI disturbances,blood dyscrasias.

History of of hypersensivity to dimenhydrinate or related drug diphenhydramine, porphyria, pregnancy. Special precautions: The drug is capable of masking symptoms of ototoxicty of certain antibiotics when used in conjunction which leads to irreversible state.

Indications:

Nausea, vomiting,dizziness,vertigo of motion sickness.

Dosage:

Adult:- Oral- 50 to 100mg every 4 to 6 hours .Do not exceed 400mg in 24 hours. IM- 50mg as needed. IV- 50mg in 10ml sod chloride injection given 2 minutes.

Children- (6 to 12 years) Oral- 25 to 50 every 6 to 8 hours Do not exceed 150mg in 24 hours. IM- 1.25mg/kg or 37.5mg/sqm 4 times a day. Do not exceed 300mg daily..

Refer Chlorpromazine 

Refer Clorpromazine - Antiemetics 

Pharmacology:

Dimenhydrinate consists of equimolar proportions of diphenhydramine and chlorotheophylline

Reports not available

Refer Clorpromazine - Antiemetics