Pamidronate disodium 30mg tab,
List of Related Indications:
- Hypercalcaemia of malignancy
List Of Drugs:
- Pamidronate disodium - @ - Bisphosphonates-(2005)
Indication Type Description:
Dosages/ Overdosage Etc
Pregnancy and lactation
Bisphonates include- Alendronate, Etidronate, Pamidronate Refer Alendronate
In patients with hypercalcamia, pamidronate has been successfully combined with both calcitron and mitramycin to acceletate and potentiate the calciun lowering effect.
Acute overdosage hypocalcaemia can occur and should be reversed by an infusion of calciun gluconate Severe or irreversible asymptotomatic pyrexia and acute-phase response may occur Thrombophlebitis in patients receiving repeated infusions Hypocalcaemia, hypophosphatemia and defective mineralisation
History of allergy to phosphonates Special precautions Mothers receiving the drug should refrain from breast feeding. Avoid during pregnancy unless there are compelling reasons Can be used in elderly persons, provided the renal function is not severely impaired
Dosages/ Overdosage Etc:
Pagets disorder of the bone
Recommended dose is - 30mg daily 9over4 hr ) for 3 consecutive days .
Max toal dose - 360mg/course May repeat course when clinically indicated Max infusion rate- 60mg/hr Elderly- initiate with lower dosages
Bisphosphonates such as pamidronate inhibit the precipitation of calcium phosphate from clear solutions and block the transformation of amorphous calcium phosphate into hydroxyapitite. Pamidronate inhibit bone resorption. Although the main effect is on the osteoclast, there is evidence to suggest that osteoblastic cells mediate the inhibitory effects of bisphophonates on osteoclasts.
The initial plasma half-life of intervenously administered opamidronate is short(< 1 hour) and the apparent plasma clearance is high. Substantial renal elimination occurs in the first 24 hours, with little detectable in urine thereafter. The terminal half-life of the drug is very long(many months). Metabolic elimination of pamidronate is not known to occur
Pregnancy and lactation:
Avoid during pregnancy unless there are compelling reasons
Mothers receiving the drug should refrain from breast feeding.