ZOSYN INJ
Brand:
ZOSYN INJ
Manufacturer:
PFIZER
Manufacturer Details
PFIZER
Compositions:
Piperacillin sod 4g + Tazobctum sodium 0.5g injection,
|
Strength
|
Rate
|
Packing Style
|
|
4g+ 0.5g
|
427.97
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4.5g vial Injection
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List of Related Indications:
- Intra-abdominal infection
- Lower respiratory tract infect
- Septicaemia
- Skin infection
- Urinary tract infections- UTI
List Of Drugs:
- Piperacillin @ - Extended Spectrum- (FDC- List )- (Aug 1989)
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Penicillins include- Natural- Penicillin G, Penicillin V Penicillase -Resistent- Cloxacillin, Docloxacillin, Methicillin, Nafacillin, Oxacillin Aminopenicillins- Amoxicillin, Amoxicillin/Potassium Clavulanate, Ampicillin, Ampicillin/Sulbactum, Becampicillin Extended spectrum- Carbenicilin, Mezlocillin, Piperacillin.Tazobactam sodium, Ticarcillin, Ticarcillin/Potassium clavulanate Refer Penicillin V Potassium
Pipercillin may inactivate aminoglycosides. Synergistic with cephalosporins, Clearance of pipercillin reduced by probenecid.
Indication:
Treatment of mixed infections.
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Piperacillin sodium Antibiotic August 1989
2.Piperacillin - Tazobactum Inj Antibiotic 13-08-1999
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
Pipercillin sodium eq.to Pipercillin 4gm/2gm + 13-08-1999
Tazobactum sodium 500mg/250mg per injection
In the treatment of lower RTI/UTI/Intra abdominal
infections, skin and structure infections, bacterial
septicemia polymicrobic infection
Adverse Reaction:
Anaphylactic reactions, rare, prolongation of bleeding time.Leucopenia, eosinophilia, electrolyte and fluid disturbances.
Contra-Indications:
Allergy to penicillins
Special precautions:
Allergy to cephalosporins,pregnancy.
Dosages/ Overdosage Etc:
Indication:
Treatment of mixed infections and presumtive therapy prior to identification of causative organisms. Also it may be used as a single drug therapy in some situations where two antibodies are normally used.
Dosage:
Administer IM or IV for serious infections: Give 3 to 4g every 4 to 6 hours as a 20 to 30 minute IV infusion. Maximum daily dosage is 24g/day. Limit IM injection to 2g/site.
Infants and children below 12 years: Dosage not established.
Following doses suggested: Neonates - 100mg/kg/day every 12 hours. Children- cystic fibrosis, 350 to 500mg/kg/day divided every 4 to 6 hours. Other conditions- 200 to 300mg/kg/day divided every 4 to 6 hours..
Patient Information:
Refer Penicillin
Pharmacology/ Pharmacokinetics:
Refer Penicillin
Interaction with Food:
Refer Penicillin
Pregnancy and lactation:
Refer Penicillin
