NUROKIND -OD
Manufacturer DetailsMANKIND
Compositions:
Mecobalamin 1500mcg fc tabs, Mecobalamin 1500mcg/ml injection,
Mecobalamin 1500mcg fc tabs, Mecobalamin 1500mcg/ml injection,
| Strength | Rate | Packing Style |
|---|---|---|
| 1500mcg f.c | 159.72 | f.c. tablets |
| 1500mcg inj | 23.99 | 1ml injection |
List of Related Indications:
- Alcoholic neuropathy
- Diabetic neuropathy
- Optic neuritis
List Of Drugs:
- Mecobalamin- (FDC- List )- (Apr 2007)
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Pharmacology/ Pharmacokinetics
Drug Interaction:
Reports not available
Indication:
U.S. FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
42. Mecobalamin 1500mcg 30-01-08
+ Alpha Lipoic Acid 100mg
+ Benfothiamine 15mg
+ B6 63mg
+ Calcium Panthothenate 25mg
+ Folic acid 1.5mg
+ Zinc oxide 22.5mg
+ Chromium
For Vitamins and Minerals deficiency states in adults
patients
44. Mecobalamin 500mcg 30-01-08
+ Alpha Lipoic acid 200mg
+ Bentofotamin 10mg
+ Pyridoxine 3mg
+ Biotin 5mg
+ Folic acid 1.5mg capsule
For Vitamin deficiency states in adult patients
90. Mecobalamn 1000mcg 19-03-08
+ Alpha Lipoic acid 200mg
+ Vitamin B6 3mg
+ Folic acid 1.5mg
+ Inositol 100mg
+ Benfotiamine 100mg capsule
For the treatment of diabetic neuropathy
151. Mecobalamin 0.5mg 03-07-08
+Alpha Lipoic Acid 100mg
+ Benfotiamin 100mg
+Pyridoxine 50mg tablets
For the treatment of diabetic Neuropathy
U.S. FDA APPROVED DRUGS DURING 2007
47. Mecobalamine 500mcg 02-04-07
+ Alpha Lipoic acid 100mg
Soft gelatin capsule For diabetic neuropathy 107. Mecobalamine 500mcg/1500mcg + 12-07-07
+ Alpha Lipoic acid 100mg
+Inositol 100mg
+Folic acid 0.5/1.5mg
+ Chromium Polynicotinate 65mcg/200mcg
+ Selenium dioxide 18/55mcg
+ Benfotamine 50/150mg capsule
For vitamins and Mineral deficiency states
in adult patients
173. Mecobalamine 0.5mg + 12-07-07
Pyridoxime 50mg+
Benfotamine 100mg capsule
For treatment of diabetic neuropathy
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Mecobalamin 750mcg 16-03-2010
+ Pyridoxine 1.5mg
+ Nicotianamide 45mg
+Befotamine 150mg Tablets
For the treatment of Diabetic Neuropathy in adults
2.Mecobalamin 750mg 27-10-2009
+ Pyridoxine Hcl 1.5mg
+ Nicotinamide 45mg tablets
For the treatment of Diabetic Neuropathy
3.Mecobalamin 500mcg 02-04-2007
+ Alpha Lioic Acid 100mg
Soft gelatin capsules
For Diabetic Neuropathy
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Mecobalamin 0.5mg + 10-03-2008
Alpha Lipoic Acid 100mg +
Benfotiamin 100mg+
Pyridoxime 50mg film coated tablet
For the treatment of diabetic Neuropathy
2.Mecobalamin 0.5mg + 03-07-2008
Alpha Lipoic Acid 100mg +
Benfotiamin 100mg +
Pyridoxime 50mg tablets
For the treatment of diabetic Neuropathy
3.Mecobalmin 1000mcg + 01-03-2008
Vitamin B1 10mg+
Vitamin B6 3mg +
Folic Acid 1mg +
Calcium Pentothenate 50mg+
Niacinamide 45mg tablet
For Vitamin and mineral deficiency states in adults
4.Mecobalamin 1000mcg + 19-03-2008
Alpha Lipoic acid 200mg +
Vitamin B6 3mg +
Folic acid 1.5mg +
Inositol 100mg +
Benfotiamine 100mg capsule
For the treatment of diabetic neuropathy
5.Mecobalamin 1500mcg + 25-02-2008
Alpha Lipoic acid 100mg +
Inositol 100mg +
Vitamin A 5000 IU +
Vitamin B1 10mg+
Pyridoxime 1.5mg+
Vitamin E 25 IU+
Calcium Pentothenate 10mg +
Folic acid 1500mcg+
Chromium 200mcg +
Selenium 163.6mcg tablet
For Vitamins and Mineral deficiency states in adults
6.Mecobalamin 1500mcg + 03-07-2008
Alpha Lipoic acid 100mg +
Vit B1 10mg+
Vit B6 3mg +
Folic acid 1.5mg capsules
For Vitamin and Mineral deficiency staes in adult
patiens
7.Mecobalamin 1500mcg + 06-09-2008
Alpha lipoic acid 100mg +
Vit B6 3mg+
Folic acid 1.5mg +
Zinc 15mg+
Chromium 60mcg +
Selenium 65mcg +
Biotin 100mcg +
Inositol 2mg tablet
For vitamin and mineral deficiency states
8. Mecobalamin 500mcg + 13-11-2007
Alpha Lipoic acid 100mg+
Folic acid 1.5mg +
Benfotiamine 50mg soft gelatin capsules
For the treatment of diabetic neuropathy in adults
9.Mecobalamin 500mcg+ 03-07-2008
Vit A 5000 IU+
Vit D3 400 IU+
Vit E 25 IU+
Vit B1 10mg+
Ribifalvin 10mg+
Vit B6 3mg+
Niacinamide 50mg +
Calcium Pentothenate 12.5mg +
Vit C 100mg+
Folic acid 1500mcg +
Biotin 60mcg+
L-Glutamic acid 100mg+
Dl Methionine 25mg+
Magnesium oxide 30mg +
Manganese 2.5mg +
Copper 2.5mg +
Zinc 22.5mg +
Chromium 100mcg
Selenium 60mcg tablets
For Vitamins and minerals deficiency states in adult patients
10. Mecobalamin 500mcg+ 29-11-2007
Zinc sulphate 61.8mg +
Calcium Pantoithenate 10mg+
Pyridoxime 3mg +
Folic acid 1.5mg +
Niacinamide 50mg +
Chromium 50mcg tablets
For vitamin & mineral deficiency states
11.Mecobalamin 0.5mg + 29-11-2007
Pyridoxime 50mg +
Bentfotiamine 100mg capsule
For thetreatmnt of diabetic neuropathy
12.Mecocobalamin 1500mcg + 30-01-2008
Alpha lipoic acid 100mg+
Bentfottiamine 5mg +
Vit B6 3mg +
Calcium Pantothenate 25mg +
Folic acid 1.5mg +
Zinc oxide 22.5mg +
Chromium Picolinate 65mcg +
Inositol 10mcg +
Lutein 5mg capsule
For Vitamin and Mineral deficiency states in adult patients
13.Mecobalamin 500mcg + 30-01-2008
Alpha Lipoic acid 200mg +
Benfotiamine 10mg +
Biotin 5mg +
Folic acid 1.5mg capsule
For vitamin deficiency states in adult patients
14. Mecobalamin 1500mcg + 12-07-2007
Alpha Lipoic acid 200mg +
Inositol 100mg +
Folic acid 1.5mg +
Chromium Polynicotinate 200mcg +
Seleno Methionine 55mcg+
Zinc monomethionine 25mg capsule
For vitamin and mineral deficiency states in adult patients
15. Mecobalmine 1500mcg + 29-11-2007
Alpha lipoic acid 100mg +
Thiamine mononitrate 10mg +
Pyridoxime 3mg +
Folic acid 1.5mg capsule
For treatment of diabetic neuropathy
16.Mecobalmine 500/1500mcg + 12-07-2007
Alpha Lipoic acid 100mg +
Inositol 100mg +
Folic acid 0.5/1.5mg +
Chromium Polynicotinate 65mcg/200mcg +
Selenium dioxide 18/55mcg +
Benfotiamine 50/150mg capsule
Fot vitamin nd mineral deficiency in adult patients
17. Mecobalamine 500mcg + 12-07-2007
Alpha lipoic acid 100mg +
Inositol 100mg +
Folic acid 0.5mg +
Chromium polynicotinate 65mcg +
Selenium oxide 18mcg capsules
For vitamin and mineral defiency in adult patients
Peripheral neuropathy
Adverse Reaction:
Gastrointestinal adverse drug reactions include anorexia, nausea, vomiting and diarrhoea. Rarely hypersensitivity reactions like rash may occur. Loss of appetite, headache, sweating, hot sensation
Contra-Indications:
Hypersensitivity discontinue if there is no response after 3 months Special precautions Reports not available
Dosages/ Overdosage Etc:
Peripheral neuropathy
Dosage
for clinical effect is 1500- 6000mcg per day in three divided doses.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Evidence indicates that methylcobalamin is utilized more efficiently than cyanocobalamin to increase levels of the coenzyme forms of vitamin B12.Methylcobalamin promotes axonal transport and axonal regeneration. It exhibits neuropathologically and electrophysiologically inhibitory effect on nerve degenaration in neuropathies induced by drugs such as adriamycin, acryfamide, and vincristine(in rats and rabbits) Human urinary excretion of methylcobalmin is about one-third that of similar dose of cyanocobalamin, indicating substantially greater tissue retension.
