Pain and Inflammation

Anti-platelet aggregation and fibrinolytic efects of bromelin may potentiate the effect of
blood thinners

Indication-

Pain and Inflammation

Dosage-
Adult- 1-2 tablets BID/TID

Pharmacology-
Trypsin is serine endopeptidase that catalyses the clevage of peptide bonds on the carboxyl
side of either arginine or lysine.
A wide range of therapeutic benefits of trypsin are fibrolytic activity, regulates cytokinase levels
and scavenges free radicals. it enhances prolteolysis and thrombolysis to promote wound healing.

Bromelain breaks peptide bonds inside protein molecules. It acts as an anti-coagulant and
anti-fibronolytic agents , prolongs the adhesion of platelets to endothelial cells of blood vessel ,
prevents edema formation and reduces existing edema. supprt skin debriment of burns and
removes cell debris by activating macrophage

Rutoside is the rutinose glycoside form of quercetin whose absoprtion appears to occur
mainly from colon following the removal of the carbohydrates moiety.  It increases the strength
of the walls of the blood capillaries and regulates the permeability so as to normalize
pathogically increased vessel permeability. It is known to have beneficial effects on capillary
 disorders.  It also has antioxidant activity, as well as anti-inflammatory , anthistaminic
and antiviral properties

Benefits of the Combination-

Based on the studies carried out, with the combination of enzymes against diclofenac in
osteoarthiritic patients, iit was concluded that the above enzyme combination
can be considered as an effective alternative to non-steroidal anti-inflammatory drugs
such as diclofenac in the treatment of painful episode of knee osteoarthiritis