Etoposide 50mg/100mg tablets and 20mg/ml injection,
|50mg/100mg tab and 20mg/ml inj||0.00||10s tablets 5ml injection|
List of Related Indications:
- Testicular cancer
List Of Drugs:
- Etoposide @- Podophyylotoxin deriv.- Mitotic inhibitors -(1983)
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Mitotic inhibitors include-
Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Refer - Etoposide
Synergism with other cytotoxic drugs.
Stomatitis, reversible alopecia.
Rarely disturbances of liver function,
Hypotension (with I.V.injection).
Hypersensitivity, severe liver dysfunction, pregnancy.
Caution in handling and preparing solutions for injection.
Skin reaction may occur with accidental exposure.
Use of gloves recommended.
If contact with skin or mucosa occurs, wash affected part with soap and water throughly.
Dosages/ Overdosage Etc:
Acute monocytic and myleomonocytic leukemias.
Parentral - 35mg/sqm/day for 4 days to 50mg/sqm/day for 5 days. Courses are repeated at 3 to 4 weks intervals. After recovery from toxicity.
Etoposides main effect appears to be at the G2 portion of the cell phase.. The predominant
macromolecular effect appears to be DNA synthesis inhibition.
The mean oral bioavailability is approx 50%. The disposition of etoposide is a biphasic process
with a distribution half-life of about 1.5 hours.
Interaction with Food:
Pregnancy and lactation:
Etoposide and tenoposide may cause fetal harm. Decide whether to discontunue the drug or not
based on the relative importance of the drug to the mother.
Not known whether the drug is excreted in breast milk. Decide whether to discontinue nursing or
the drug depending on the importance of the drug to the mother.