Alkem laboratories Ltd. Dev Asish Bldg,Near Mautulya Centre Senapati Bapat Marg, Lower Parel Mumbai 400013
Vincristine 1mg/1ml injection,
List of Related Indications:
- Acute lymphoblastic leukaemia ( ALL )
List Of Drugs:
- Vincristine ( * ) - @-Mitotic inhibitors
Indication Type Description:
Dosages/ Overdosage Etc
Interaction with Food
Pregnancy and lactation
Mitotic inhibitors include- Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Myleosupression. Neuromuscular toxicity, Hyperuremia,brochospasm, azosperma, Menorrhoea, alopecia, Leucopenia, pain,
Constipation, Paralytic ileus, Urinary dysfunction.
Patients with a form of Charcot-Marie tooth syndrome.
Acute uric acid neuropathy may occur. Care in patients with leucopenia or a complicating infection.
Cytocristin should not be given to patients receiving radiation therapy through parts include liver. Pregnancy, lactation.
Dosages/ Overdosage Etc:
Indications: Acute leukemia
Dosage: Cautiously calculate and administer dose.
Over dosage may be serious or fatal
. Adults- 1.4 mg/sqm. For children weighing less than 10 kg or a body surface area less than 1sqm., give 0.05 mg/kg once a week.
Hyponatremia indicates that the body fluids are diluted by an excess of water relative to total solute. Most types of hyponatremia can be considered to result from defective urinary dilutuion . Normal watervdilutiuon requires three factors
1. Secretion of ADH must be suppressed.
2. Sufficient sodium and water must reach the diluting sites of the nephron, in the asending limb of Henles loop and the distal convoluted tubule
3. Therse nephron segments must function normally , reabsorbing sodium while remaing impermeable to water.
Drugs causing adverse reactions- Dilutional
Drugs causing adverse reactions- Salt wasting
2. Corticosteroids- withdrawal
3. Enema 4. Mannitol
Vincristine sulphate is an alkaloid from the periwinkle. Mode of action is unknown. In vitro, it arrests mitotic divison at metaphase. Antineoplastic effects are related to interference with intracellular tubulin function.
Within 15 to 30 minutes following IV admin. more than 90% of the drug is distributed from blood to tissue where it remains tightly, but not irreversibly bound. The liver is the major excretory organ more than 80% of a dose appears in feces and 10 to 20% in the urine.
Interaction with Food:
Pregnancy and lactation:
Use contraindicated. Observe caution