VitaminC (Ascorbic acid) - @- Water sol vitamins
Drug Name:VitaminC (Ascorbic acid) - @- Water sol vitamins
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Other Information
Patient Information
Interaction with Food
Pregnancy and lactation
Drug Interaction:
Interacting drugs- summary
Ascorbic acid +
Contraceptives, oral and oestrogens-
Ascorbic acid increases serum levels of oestrogens and
oestrogen containing contraseptives, resulting in
adverse reactions.
Warfarin-
anticoagulant action of warfarin reduced.
Indication:
Scurvy
Adverse Reaction:
Large doses may cause diarrhoea and precipitation of cystine oxalates or urate stones if the urine becomes acidic during therapy.
Transcient mild soreness may occur at the site of IM or SC injection.
Too rapid IV administration may cause temporary faintness or dizziness.
Contra-Indications:
None reported.
Special precautions:
Excessive vitamin C doses- diabetics, patients prone to renal calculli,those undergoing stool occult blood tests and those on sodium restricted diets or anticoagulant therapy should not take excessive doses of vitamin C over the extended period of time.
Pregnancy- not known whether ascorbic acid can cause fetal harm or can affect reproduction capacity.
Give to pregnant women only if needed. Do not administer to pregnant women in excess of the amount needed.
Lactation- administer with caution to nursing mother. Ascorbic acid is excreted in breast milk, but does not necessarily increase in response to increasing doses.
Dosages/ Overdosage Etc:
Indications: Scurvy
Dosage: Average dose 75 to 100 mg/day
Scurvy- 300 mg to 1 g daily
Other Information:
ANTIOXIDANTS AND METHYLATING AGENTS
Folic acid, pyridoxine, cyanocobalamin
Folic acid is esstential for cell replication and growth. It is required for the synthesis for DNA proteins, RBCs and for energy production
Pyridoxine (Vitamin B6) functions as a co-enzyme in synthesis of haeme, neurotransmitters and nucleic acid.
Cynanocobalamin (vitamin B-12) acts as a co-factor in the conversion of methylmalonyl-co A to succinyl-coA in homocysteine metabolism, the B-vitamin folate, B-12 and B-6 function as essential cofactors and coenzymes in regulating the remethylation and trans-sulfuration pathways. Studies show that a good number of the adult
population are deficient in these three vitamins.
Choline- Choline is required for the synthesis of phospholipids, phosphatidyl choline and spingomycetin -the structural components for all human cell membranes. Choline is a precursor for acetylcholine, an important neurotransmitter involved in muscle control, memory and many other functions.
Betaine, a derivative of choline is a source of methyl groups required for methylation reactions. Methyl groups from betaine may be used to convert homocysteine to methionine. The role of choline in methylation probably explains the finding that choline-deficient diets are associated with an increased rate of cancer in animal studies.
Choline have a beneficial role in neurodegenerative disorders.
Methionine- It is an essential amino acid and a principal supplier of sulfur, which prevents disorders of the hair, skin and nails.It also helps in lowering the cholesterol levels by increasing the hepatic production of lecithin. It also reduces hepatic
fat, protects the kidneys, regulates the formation of ammonia, influences hair follicles and promotes hair growth. It is a natural chelating agent for heavy metals.
Lycopene-It is a potent antioxidant carotenoid present in tomatoes. It s supplementation has been shown to be associated with a decreased risk of cardiac disease, cancer of the prostrate, breast, lung, colon, endometrium and cervix
Vitamin C- It is a water soluble antioxidant that scavenges superoxide, hydroxyl radicals and single oxygen. It protects against cancer cell growth by destroying free radicals, increasing collagen synthesis, altering DNA and protein metabolism
preventing transformation of precancerous cells to cancerous cells and producing cytotoxicity in cancer cells In epidemological studies.
Vitamin C has been shown to have a protective effect in preventing and treating oesophageal , oral pharyngeal, stomach, lung, cervical, rectal, colon, and pancreatic cancer. In addition,supplementation with the combination of Vitamin C and Vitamin E has shown to slow down artherosclerotic progression in hypercholesterolemic persons.
Vitamin E- It helps to prevent oxidation of ployunsaturatted fatty acids and fat soluble vitamins in the body and stimulates the immune system to destroy tumor cells as they are transformed to cancerous state. It has been shown to prevent cancer and cardiovascular disease. It also aids in normal blood clotting and healing. Vitamin E intake from food
or supplements is also associated with less congnitive decline with age and may have an important role in neurodegenerative disorders.
Selenium- Se;enium acts as an antioxidant by activating the enzyme glutathione peroxidase. People living in areas with selenium -poor soils are found to have higher cancer rates than those living in selenium-rich soils areas.
Red bush tea extract - Also known as Rooibos tea extract, it is caffeine free and has a low tannin content. It is highly defensive natural antioxidant including falvanoids. Because of its contents, it may be antiaging, particularly in preventing age-related byproduts of oxidaton of the brain. It was shown to inhibit the cancer causing- causing effect of X_Rays in test
animals. It has also been successfully used in the management of various dermatolgical conditions.
Containdications:
Hypersensitivity to any ingredients
Precautions:
Urine may give a false positive result by Benedicts test because of the presence of absorbic acid (Vitamin C)
Summary
Oxidative damage and antioxidant deficiency impacts on wide range of human diseases.
Several studies show that antioxidants like Vitamin C, Vitamin E, Selenium, carotenoids and methylating agents like the B-group Vitamins and choline have a beneficial effect in the prevention of chronic diseases.
Thus the combination of these nutrients may help prevent a host of diseases including cancer, cardiovascular disease and other chronic diseases.
Patient Information:
Ascorbic acid - Vitamin C - Systemic
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to ascorbic acid
Also tell your healthcare provider if you are allergic to any other substances,
such as foods, sulfites, or other preservatives or dyes.
2.Pregnancy-
It is especially important that you are receiving enough vitamins when you become
pregnant and that you continue to receive the right amount of vitamins througout
your pregnancy. Healthy fetal growth and development depend on a steady supply
of nutrient from mother to fetus.
However, taking too much vitamin C daily throughout the pregnancy may harm
the fetus.
3. Breast-feeding-
It is especially important that you receive the right amounts of vitamins so that
your baby will also get the vitamins needed to grow properly. You should also check
with your doctor if you are giving your baby an unfortied formula. In that case, the
baby must get the vitamins needed some other way. However, taking large amounts
of a dietary supplement while breast-feeding may be harmful to the mother and /or
baby and should be avoided.
4.Children-
Problem in children have not been reported with intake of normal daily
recommended amounts.
5.Older adults-
Problems in older adults have not been reported with intake of normal daily
recommended amounts.
6.Other medicines-
Although certain medicines or dietary supplements should not be used together
at all, in other cases two different medicines may be used together even interaction
might occur. In such cases your doctor may want to change the dose , or other
precautions may be necessary.
Tell your doctor if you are using any other prescription or nonprescription
(over- the- counter OTC) medicine
7.Other medical problems-
The presence of other medical problems may affect the use of Vitamin C.
Make sure you tell your doctor if you have other any other medical problems,
especially-
Blood problems- high doses of vitamin C may cause certain blood problems
Diabetes mellitus- (sugar diabetes) - very high doses of vitamin C may, interfere
with tests for sugar in the urine
Glucose-6-phosphate-defeciency- (G6PD) - high doses of vitamin C may cause
hemolytic anemia
Kidney stones- (history of)- high doses of vitamin C may increase risk of
kidney stones in the utinary tract.
Interaction with Food:
Not significant
Pregnancy and lactation:
Pregnancy
not known whether ascorbic acid can cause fetal harm or can affect reproduction capacity. Give to pregnant women only if needed. Do not administer to pregnant women in excess of the amount needed.
Lactation
administer with caution to nursing mother. Ascorbic acid is excreted in breast milk, but does not necessarily increase in response to increasing doses.
