Anorexiants include-

Phenetermine Hcl, Benzphentamine Hcl, phenetrazine Hcl, Phendimetrazine tartarate, Diethylpropion Hcl, Mazindol, Fenfluramine, Sibutramine

Refer - Dexfenfluramine HCl 

CNS depression with alcohol and other CNS depressants. Hypertensive crisis with MAOIs. Potentiates guanethidine, methyldopa, reserpine. Cardiac arrest with anaesthetics. Effect of antidiabitis potentiated. Useful adjuvant to sulphonylureas in obese NIDDM.

Anorexiants include-

Phenetermine Hcl, Benzphentamine Hcl, phenetrazine Hcl, Phendimetrazine tartarate, Diethylpropion Hcl, Mazindol, Fenfluramine, Sibutramine

Refer - Dexfenfluramine HCl

Blood dyscrasias. Abuse potential, impairment in hazardous activities, depression, pulmonary hypertension, drowsiness, diarrhoea, dry mouth, confusion, incordination, palpitation, hypo or hypertension, sweating, chills, dysuria, rash, eye irritation, myalgia, fever. Depression on abrupt withdrawal.

1st trimester of pregnancy.Concomittant admin of NAOIs. Depressive illness, epilepsy, alcohol or drug abuse. Special precautions: The drug may enhance the effects of antihypertensives, antidiabetics and sedatives. Reasscess the dose in such cases. Pregnancy and lactation.

Indications:

Anorexiant

Dosage:

Usual dose- 20mg 3 times daily, may increase at weekly intervals by 20mg

. Daily maximum of 40mg 3 times daily.

1. May cause insomnia, avoid taking medication late in the day.

2. Weight reduction requires strict adherance to dietary restriction.

3. Do not take more frequently than prescribed.

4. Notify physician if palpitations, nervousness or dizziness occurs.

5. Medicatin may cause dry mouth and constipation, notify physician if these become pronounced

6. May produce dizziness or blurred vision; observe caution while driving or performing tasks requiring alertness.

7. Allergies- Tell your doctor if you have ever had any unusual or allergic reactions to this medicine or amphetamine dextroamphetamine, ephedrine, epinephrine, isoproterenol, metaproterenol, methaamphetamine, norepinephrine, phenylephrine, phenylpropanolamine , pseudoephedrine, terbutaline, or other appetite suppresants. Also tell your doctor if your are allergic to any other substances such as foods, preservatives or dyes.

8. Pregnancy- animal studies have shown that fenfluramine when given many times the human dose reduces fertility and may have toxic or harmful effects on the fetus.

9. Breast feeding- this medicine has not ben reported to cause problems in nursing babies

10. Children- fenfuramine should not be used as an appetite suppressant by children under 12 years of age

11. Elderly- there is no specific information comparing use of fenfluramine in the elderly to use in other age groups

12. Other medicines- tell your doctor if you are taking any of the following- Central nervous system depressants or Tricyclic antidepressants - use of these medicines with fenfluramine may increase the CNS depressant effects Monmoamineoxidase inhibitors- MAOI- taking fenfuramine while you are taking or within 2 weeks of taking MAOI may cause sudden extremely high blood pressure at least 14 days should be allowed between stopping treatment with one medicine and starting treatment with the other.

13. Other medical problems- presence of other medical problems may affect the use of this medicine- Alcohol abuse or Drug abuse or dependence may develop Diabetes mellitus - the amount of insulin or oral antidiabetic medicine that you need to take may change Glaucoma or Heart or blood vessel disease or Mental depression or Mental illness -fenfluramine may make the condition worse

14. Missed dose- If you miss a dose of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double doses.

Pharmacology:

The nonamphetamine anorexiants are indirect acting sympathomimetics amines. The exact mechanism of action has not been established. It is thought to be that appetite supression is produced by a direct stimulant effect on the satiety center in the hypothalamic and limbic regions.

Pharmacokinetics:

After oral admin the immediate release dosage exerts thier effects for 4 to 6 hours. Fenfuramine is well absorbed from the GI tract and a maximum anorectic effect generally occurs in 2 to 4 hours.

Reports not available

Pregnancy:

Contraindicated during pregnancy

Lactation:

Safety for use in nursing mothers has not been estabkished.