Drug Interaction:
Analbolic steroids include-
Oxymetholone, Stanazolol, Oxandrolone, Nandrolone phenpropionate, Nandrolone deconate,
Refer - Nandrolone
Increased risks of haemorrhage with anticoagulants. Potentiates hypoglycaemic agents.
Drugs which induce liver enzymes (Rifampicin,Phenytoin) reduce effect of oxymetholone.
Indication:
Anemia produced by deficient red cell production.
Analbolic steroids include- Oxymetholone, Stanazolol, Oxandrolone, Nandrolone phenpropionate, Nandrolone deconate,
Refer - Nandrolone
Adverse Reaction:
Possible development of neoplasm and leukaemia.
Exacerbation of Ca prostrate. Retension of salt and water, increased skin vascularity, nitrogen retension, hypocalcaemia, impaired glucose tolerance increased skeletal weight. Increased LDL, decreased HDL, jaundice, altered libido.
Males:
Priasism, gynaecomastia. Women:Supression of ovarian activity and menstruation, virilism. Children:Growth retardation, precocious puberty.
Contra-Indications:
Ca prostrate,Ca male breast,severe liver dysfunction, pregnancy.
Special precautions:
CVS disorders, liver/renal impairment, epilepsy, diabetes, migraine, lactation.
Dosages/ Overdosage Etc:
Indications:
Anemia produced by deficient red cell production.
Dosage:
1 to 5mg/kg/day. The usual effective dose is 1 to 2mg/kg/day. Individualise dose.
Patient Information:
1. Diabetic patients- Glucose tolerance may be altered.; monitor urine sugar closely and report abnormalities to physician.
2. Female patients- Notify physician if hoarseness, deepening of the voice, male-pattern baldness, menstrual irregularities or acne occurs.
3. May cause nausea or GI upset. Notify if nausea, vomiting, changes in skin colour or ankles swelling occurs.
Anabolic steroids-
1. Allergies- Tell your doctor if you have ever had any unusual allergic reactions to anabolic steroids or androgens
2. Pregnancy- Anabolc stretoids are not recommended during pregnancy. They may cause the development of male features in the feamale fetus and premature growth and development of female features in the male fetus.
3. Breast-feeding- Threre is very little experience with their use in mothers who are breat feeding.
4. Children- Anabolic steroids may cause chilfdren growing. In addition they may make male children develop too fast sexually and may cause male-like chages in female children.
5. Elderly- When the elderly patients are treated with anabolic steroids they may have an increased risk of enlarged prostrate or cancer of the prostrate
6. Certain medicines- When you taking anabolic steroids it is especially important that your doctor know that you are taking the following- Acetaminophen, amiodarone, andrgens( male hormones) anti-thyroid agents, anti-infectives by mouth or injections Carbamazepine, carmustine, chloroquine Dantrolene, daunorubin,disulfram, divalproex Estrolgens (female hormones) eretinate Gold salts Hydroxychlorquine Mercaptopurine, methotrexate, methyldopa, Naltrexone Oral contraceptives Phenothiazine,phenytoin, pilamycin Valproic acid Anticoagulants
7. Other medical problems- Presence of other medical problems may afect the useof anabolic steroids Breast cancer or Diabetic mellitus or Enlarged prostrate or Prostatic cancer Heart or blood vessel disease kidney disease Liver disease Too much calcium in the blood.
8. Missed dose- if you miss a dose of this medicine and yourdosing is- One dose a day- Take the missed dose as soon as possible. However, if you do not remember it until the next day skip the missed dose and go back to your regular dosing Do not double doses.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Anabolic steroids promote body-tissue building processes and reverse catabolic or tissue depleting processes. dminister adequatq calories and protein to acheive positive nitrogen balance.
Interaction with Food:
Reports not available
Pregnancy and lactation:
Pregnancy:
Contraindicated because of possible fetal masculinization
Lactation:
Not known whether anabolic steroids are excreted in breast milk. Observe caution and decide weighing the benefit to the patient against the potential hazard to the nursing infant.
Children:
Safety and efficacy for use in children has not been established.