Warfarin, theophylline, aspirin,, Erythromycin, smoking Caution with drugs metabolized by CYP2C9 eg.tolbutamide, phenytoin, carbamazepine, or CYP3A4 eg, dihydropyrridine, cal channel blockers, cyclosporine, cisapride

Headache, g-i upset, rash, priritus, Malaise, increased serum transaminases, Discontinue tgherapy immediately following signs or symptoms of liver dysfunction

Respiratory infections in elderly Insomnia , irritability, restlessness,

Depression, suicidal thinking and behavoiur, Hallucinations, coinsider discontinuing therapy Rarely ,hepatitis, bruising bleeding, myalgia, Patients should be asked to report nausea,

Fatigue,loss of appetite, flu-like symptoms, Pain on right side of abdomen, Yellow coloration of the eyes Dark urine to doctor urgently

hepatic impairment , cirrhosis, hypersensitivity, lactation.

Special precautions

Do not substitute for steroid therapy or use for acute attacks Moderate to severe renal impairment

Elderly, pregnancy

Discontinue if eosinophilic condition or a Chrug -Strauss syndrome develops

If signs or symptoms of hepatic impairment, measure transaminase and consider withdrawing therapy

Prophylaxis and treatment of asthma

Dosage-

1 tab twice daily between meals children - not recommended

Use contraindicated. Observe caution