Drug Interaction:
Interacting drugs- summary
+ Dextromethorphan
MAOI +
patients develop hypotension, hyperpyrexia, nausea, myoclonic leg jerks and coma following coadministration
MAOI + Dextromethorphan MAOI incr patients develop hypotension, hyperpyrexia, nausea, myoclonic leg jerks and coma following coadministration
Indication:
U.S FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
37. Dextromethorphan Orodispersible strip 28-01-08
5.5mg/11mg
For the relief of persistent dry irritating cough in
adult patients only
U.S FDA APPROVED DRUGS DURING 2007
185. Dextromethaphan HBr 10mg 12-11-07
+chlorphenaramine maleate 2mg/5ml syrup
For the temporary relief of cough due to throat
irritation, sneezing & running nose
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Dextromethorphan HBR 10mg+ 12-11-2007
Chloropheneramine maleate 2mg/5ml syrup
For the temporary relief of cough due to throat irritation , sneezing,
and running nose
2. Dextromethorphan HBR ER suspension 01-08-2013
30mg/5ml - Addl Dosage Form
For the relief of persistent dry irritating cough in adults patients
only
3. Dextromethorphan ER Oral suspension 17-01-2011
30mg/5ml
For the relief of persistent dry irritating cough in adults patients
only
4. Dextromethorphan Orodispersable strip 28-01-2008
5.5mg/11mg
For the relief of persistent dry irritating cough in adult patients
only
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
Dextrometharphan Hbr 10mg+ 12-11-2007
Chlorapheneramine maleate 2mg /5ml syrup
For the temporary relief of cough due to throat
iritation, sneezing and running nose
Adverse Reaction:
Dizziness, GI disturbances, excitation, confusion.
Contra-Indications:
Concomittant use of MAOIs. Special precautions: Liver disease, respiratory failure.
Dosages/ Overdosage Etc:
Date o Approval 2007
For the relief of persistent dry irritating cough in adult patients only
Indications:
To control non-productive cough
Dosage:
Adults and children(more than 12 years old)- 10 to 30mg every 4 to 8 hours. Do not exceed 120mg in 24 hours.
Children
(6 to 12 years)- 5 to 10mg every 4 hours or 15mg every 6 to 8 hours.Do not exceed 60mg in 24 hours.
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
1. Allergies- Tell your doctor if you have ever had any unusual or allergic reactions to dextromethorphan or other related medicines. Also tell your doctor if youn are allergic to any other substances such as foods, preservatives or dyes.
2. Diet- make sure that your doctor knows if you are on a low salt sodium, low sugar or any other special diet.
3. Pregnancy- dextromethorphan has not been to cause birth defects or other problems in humans.
4. Breast feeding- dextromethorphan has not been reported to cause problems to nursing babies
5. Children- has not shown to casue different side effects or problems than it does in adults.
6. Elderly- no specific information comparing use of dextromethorphan in the elderly in other age groups 6. Other medicines- tell your doctor if you are taking any of the following- Central nervous system CNS depressants- effects of either medicines or dextromethorphan may be increased MAO oxidase inhibitors- -taking dextromethorphan if you are taking MAO inhibitors or taken them within the past 2 weeks may cause coma, dizziness, excited or unusual behaviour , fever, high blood pressure nausea, sluggishness, spasms, and tremors
7. Other medical problems- tell your doctor if you have any other medical problems- Asthma- since dextromethorphan decreases coughing it makes it difficult to get rid of the mucus that collect in thelungs and lungs during asthma Liver disease- dextromethorphan may build up n the body and cause unwanted effects. Mucus of phlem with cough- since dextromethorphan decreases coughing it makes it difficult to get rid of the mucus that collect in the lungs and airways with some diseases
8. Missed dose- If you miss a dose of this medicine take it as soon as possible. However if it is almost time for your next dose go back to your regular dosing schedule. Do not double doses.
Pharmacology/ Pharmacokinetics:
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