Drug Interaction:
Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol, Solatol, Timolol, Refer - Atenolol
Marked hypertension and bradycardia with adrenaline.
Potentiation of bradycardia with anaethestics.
Rebound hypertension with clonidine enhanced.
Masks signs of hypoglycaemia in diabetes and hypertension associated with hypoglycaemia is prolonged.
Absorption by food.
Hypotensive action may be reduced by indomethicin.
Inhibits tachycardia produced by vasodilators (hydrazine and minoxidil).
Indication:
U.S FDA APPROVED FROM 01-01-08 TO 31-12-08
Drug name Indication Date of Approval
235. Timolol maleate SR Eye drops 5.0mg/ml 08-11-08
+Benzoyl Peroxide 2.5% gel
For the treatment of elevated intraocular pressure
in patients with ocular hypertension or open angle
glaucoma
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing (Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Timolol Maleate Long acting 14-05-2010
Ophthalmic Solution 5mg/ml
For the treatment of Elevated Intraocular Pressure in patients with
Ocular hypertension or Open Angle Glaucoma
2.Timolol Maleate SR eye drops 08-11-2008
0.5mg/ml
For the treatment of Elevated Intraocular Pressure in patients with
Ocular hypertension or Open Angle Glaucoma
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
Timolol Maleate 5mg (as based) + 25-01-2000
Pilocarpine hcl 20mg per ml
Ophthalmic solution
For reduction of ocular pressure in patients & other
hypertension or open angle glaucoma
Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol, Solatol, Timolol, Refer - Atenolol
Adverse Reaction:
Sudden withdrawal in patients with IHD may worsen the condition. Heart failure, heart block, brochospasm.
Fatigue, coldness of extremities, parathesisas, GI symptoms, skin rash, alopecia, dryness of eye, blurred vision, thrombocytopenia.
Opthalmic use: Occular irritation, blepharitis, keratitis, decreased corneal sensitivity, visual disturbances, diplopia and ptosis. Systemic absorption withsystemic effect may occur.
Contra-Indications:
Hypersens to ingredients,heart block (second/third degree).
Special precautions:
Due to systemic absorption, side effects associated with beta-blockers may occur. Caution in patients with COPD or CHF. Safety in children & pregnant women not established. Hypoglycaemia.
Dosages/ Overdosage Etc:
Indications: Hypertension, Myocardial infaction, Migraine prophylaxis.
Dosage: Initial- 10 mg twice daily. Used alone or with a diuretic. Maintenance dose- 20 to 40 mg/day. Titrate depending on blood pressure and heart rate.
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
Refer - Atenolol
Pharmacology/ Pharmacokinetics:
Ref- Drug Facts And comparisons(2010)
Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol,
Solatol, Timolol,
Refer - Atenolol
Beta-adrenergic ophthalmic blocking agent- Carteolol, Betaxolol, Levobunolol,
Metipranol, Timolol
Refer- Timilolol
Pharmacology-
Timilol, levobunolol, cartelol, and metipranol are non-cardio-selective (B1 and B2)
Beta blockers, Betaxolol, is a cardioselective B1 Beta blocker. Topical Beta-blockers
do not have significant membrane stabilizing (local- anesthetic actions or intrinsic
sympathomimetic activity. They reduce the elevated and normal IOP, with or without
glaucoma
Pharmacokinetics-
Pharmacokinetic of Ophthalmic Beta- Adrenergic blocking Agents
Parameters
Beta-receptor Onset Maximum effect Duration
selectivity (min) (hr) (hr)
Drug
Carteolol
B1 and B2 nd 2 12
Betaxolol
B1 <30 2 12
Levobunolol
B1 and B2 <30 2 to 6 <24
Metipranolol
B1 and B2 <30 ~2 24
Timolol
B1 and B2 <30 1 to 2 <24
Pregnancy and lactation:
Refer- Atenolol- Beta-adrenergic blocker
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