MAOIs , anti-depressants affecting nor-adrenergic transmission CNS depressants , Anti-hypertensives, Cardiac glycosides, sympathomimetics agonists or antagonists

Ocular hyperaremia, conjuntivitival follicles. Stinging pruritus, oedema Blurring,itching, burning, allergy, Dryness, pain, Dry mouth, headache, Fatigue, asthenia, drowsiness, dizziness, Dysgeusia, visual disturbances Upper respiratory symptoms GI upset Foreign body sensation Corneal staining Photophobia Blepharitis

Neonates and infants less than 2 years of age Concurrent MAOIs therapy Lactation

Special precautions-

Severe cardio-vascular disease

Depression, cerbral or coronary insufficiency

Reynauds syndrome Orthostatic hypotension Thrombo-angilis obliterans

Renal or hepatic impairment Soft contact lenses Wait minimum 15 minutes before inserting Pregnancy

Glaucoma or ocular hypertension

Dosage-

1 drop in the affected eye(s ) twice daily approx. 12 hours apart

Children- not recommended

 PATIENT COUNSELING INFORMATION

As with other drugs in this class, Brimonidine Tartrate Ophthalmic Solution, 0.15% may cause fatigue and/or drowsiness in some patients.

Patients who engage in hazardous activities should be cautioned of the potential for a decrease in mental alertness. Rx Only

Distributed by: Falcon Pharmaceuticals, Ltd. Fort Worth, Texas 76134 Manufactured by: Alcon Research, Ltd. Fort Worth, Texas 76134 Printed in USA

Use contraindicated Observe caution if required to be used