Formulation comprising of Polyvinyl alcohol 1.4% + Povodone 0.6% w/w No information is available on drug interactions. The incompatibility problems associated with the constituents of this combination are presented bleow: Polyvinyl alcohol decomposes in strong acids and softens or dissolves in weak acids and alkalis. Incompatible with most inorganic salts especially sulfates and phosphates. Borax is a particularly effective gelling agent for polyvinyl alcohol solutions Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins and other chemicals.

Dry eye syndrome

Although this combination alleviated dry eye syndrome, as per the reports, this formulation may show transcient burning or stinging sensation following its instillation.

Hypersensitivity to either components of the combination

Special precaution

If irritation persists or increases , discontinue use and consult an eye specialist The formulation is for single use only. Do not touch dropper tip to any surface and keep the container tightly closed.

Since there is no information regarding the use of this combination in pregnant and nursing women ,carefully study and assess the matter in these populations

Parentral administration (I.M.) of povidone is associated with the accumulation of the drug in the organs of the body.

Studies in rats have shown that 5% polyvinyl alcohol aqueous solution injected subcutaneously can cause anemia and infiltrate various organs and tissues.

Dry eye syndrome

Dosage-

The combination formulation ( polyvinyl alcohol 1.4% + Povidone 06% W/v) is for single use only

The recommended dose is 1-2 drops (dfrom each unit instilled into the affected eye(s) 3-4 times daily or as required depending on the severity of the clinical condition. Discard any unsued portion.

1. If irritation persists or increases , discontinue use and consult an eye specialist

2. The formulation is for single use only. Do not touch dropper tip to any surface and keep the container tightly closed.

3. Since there is no information regarding the use of this combination in pregnant and nursing women ,carefully study and assess the matter in these populations.

Pharmacology:

Patients with severe dry eyes usually responds to treatment with eye drops or artificial tears containing compounds such as polyvinyl alcohol, povidone, carbomer, hypromellose and other cellular ethers. The advantages associated with effective tear substitute formulation include- effective management of dry eyes syndrome use in patients sensitive to perservatives and in contact lens wearers

Ployvinyl alcohol being a nonionic surfactant , it is soluble in water. It is used as stabilising agent and as lubricant in various opthalmic preparations. The viscocity enhancing property in prolonging contact of the active ingrendient with eye is expected to produce better results.

Povodone is a synthetic polymer used as artificial tears as as solution for contact lens care. The solubility of a number of poorly soluble active drugs may be increased by mixing with poviodone

Since there is no information regarding the use of this combination in pregnant and nursing women ,carefully study and assess the matter in these populations