Antihistamines Include: First Generation ( Non-selective )  Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine

Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine Refer - Chlorpheniramine maleate

Enhances CNS depression of alcohol,barbiturates, hypnotics, sedatives, analgesics. Tricyclic anti-depressants have additive effects. Masks ototoxicity produced by aminoglycoside antibiotics

Allergic and ocular allergies

Antihistamines Include: First Generation ( Non-selective )  Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine

Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine Refer - Chlorpheniramine maleate

CNS depression,paradoxical CNS excitation, dryness of mouth, thickened respiratory mucous,urinary retension, constipation tachycardia,arrhymias, blurring of vision, GI upsets, blood dyscrasias.

Topical appln: Sensitisation.

Neonates, infants, pregnancy, urinary retension, paralytic ileus.

Special precautions:

Elderly, closed angle glaucoma,BHP, driving, epilepsy, G.I.T. obstruction.

Indication-

Allergic and ocular allergies

Dosage-

Adults and children over 6 years- 1 tab thrice daily Upto 6 years - 1/2 tab 1-3 times daily