Fexofenadine hcl - @ - Antihistamines- (FDC- List )- (Jan 2007)
Drug Name:Fexofenadine hcl - @ - Antihistamines- (FDC- List )- (Jan 2007)
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Pharmacology/ Pharmacokinetics
Pregnancy and lactation
Drug Interaction:
Antihistamines Include: First Generation ( Non-selective )
Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine
Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine
Refer - Chlorpheniramine maleate
Fexofenadine +
Ketoconazole/ Erythromycin-
Co-administration of fexofenadine with ketoconazole and erythromycin lead to an increase in plasma levels of fexofenadine, while fexofenadine had no effect on the pharmacokinetics of erythromycin and ketoconazole
Indication:
Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine
Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine
Refer - Chlorpheniramine maleate
Adverse Reaction:
Viral infections,cold, flu, nausea, dysmenorrhea, dyspepsia, fatigue, headache, throat irritation.
Contra-Indications:
Hypersensity Special precautions: Use with caution during pregnancy and lactation. Not recommended for children below 12 years Patients with renal impairment
Dosages/ Overdosage Etc:
Allergic conditions
Dosage-
Adults and children over 12 years: 60mg b.i.d. in patients with decreased renal function 60mg once daily
Patient Information:
Antihistamines Include: First Generation ( Non-selective )
Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine
Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine
Refer - Chlorpheniramine maleate
Pharmacology/ Pharmacokinetics:
Pharmacology:
Fexofenadine is a metabolite of terfenadine, showing selective H-receptor antogonist activity. It inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.
Pharmacokinetics:
The mean plasma concentration was reportedly 209ng/ml. The pharmacokinetics of fexofenadine was found to be linear for oral doses up to 120mg twice daily
Pregnancy and lactation:
Not recommended for use during pregnancy and lactation
