Antihistamines Include:

Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine, Triprolidine Phenothiazines- Methidilazine, Promethizine Piperadines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine

Refer Chlorphenramine maleate

Allergic conditions

CNS depression, paradoxical stimulation (children), Dryness of mouth, thickened respiratory secretion, Blurring of vision, Constipation, Urinary retension, Bradycardia followed by tachycardia and arrhythmias, GI disturbances, and blood dyscrasias.

Hypersensitivity, closed angle glaucoma, pregancy, CV disease.

Special precautions:

Epilepsy, elderly, lactation, urinary and GI obstruction, driving.

Indications:

Allergic conditions

Dosage: Oral - adults- 25 to 50mg 3 times a day. Children- 12.5 to 25mg 3 times a day.

Parentral- Adult-

10 to 50mg IV or deep IM. Max daily dose 400mg Children- 5mg/kg/24 hours in 4 divided dose IV or deep IM. Max daily dose 300mg.

1. Inform patients of a history of glaucoma, peptic ulcer, urinary retention, or pregnancy before starting antihistamine therapy

2. May cause nervousness, insomnia, and dry mouth

3. May cause drowsiness, or dizziness(except astemazole,loratadine, and tefenadine)

4. Patients should observe caution while driving or performing other tasks requiring alertness, coordination or physical dexterity.

5. Avoid alcohol and other CNS depressants (eg,. sedatives, hypnotics, tranquilizers)

6. May cause GI upset, take with food. Take Astemazole on an empty stomach, at least 2 hours after or 1 hour before a meal. Take Lorantidine on an empty stomach.

7. Avoid prolonged exposure to sunlight, may cause photosentivity.

8. Do not crush or chew sustained releae preparations

9.Astemazole/ Terfenadine: Patients should not take these agents if they have hepatic dysfunction or if they are also receiving ketoconazole, itraconazole or erythromycin

10. Phenothiazines- Patients should report any involuntary muscle movements or unusual sensitivity to sunlight.

Refer antihistamines

None reported

Refer antihistamines