Antihistamines Include: First Generation ( Non-selective )

 Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine Phenothiazines- Methidilazine, Promethizine, trimeprazine

 Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine

Refer - Chlorpheniramine maleate 

Cough 

CNS depression, pardoxical excitation (children). Dry mouth, blurring of vision, Constipation, Retension of urine, Bradycardia followed by tachycardia and arrhythmias. G.I. disturbances, Blood dyscrasias, Giddiness, Hypotension and headache.

Neonates, hypersens, narrow angle glaucoma, pregnancy, GIT/urinary outflow obstruction, paralytic ileus.

Special precautions:

Elderly, driving, avoid alcohol, peptic ulcer, epilepsy, severe CVS disease, lactation, BHP.

Indications:

Cough

Dosage:

Adults- 8mg 4 times daily.

 1. Inform patients of a history of glaucoma, peptic ulcer, urinary retention, or pregnancy before starting antihistamine therapy

2. May cause nervousness, insomnia, and dry mouth

3. May cause drowsiness, or dizziness(except astemazole,loratadine, and tefenadine)

4. Patients should observe caution while driving or performing other tasks requiring alertness, coordination or physical dexterity

. 5. Avoid alcohol and other CNS depressants (eg,. sedatives, hypnotics, tranquilizers)

6. May cause GI upset, take with food. Take Astemazole on an empty stomach, at least 2 hours after or 1 hour before a meal. Take Lorantidine on an empty stomach.

7. Avoid prolonged exposure to sunlight, may cause photosentivity.

8. Do not crush or chew sustained releae preparations

9.Astemazole/ Terfenadine: Patients should not take these agents if they have hepatic dysfunction or if they are also receiving ketoconazole, itraconazole or erythromycin

10. Phenothiazines- Patients should report any involuntary muscle movements or unusual sensitivity to sunlight.

Refer - Chlorpheniramine maleate

Refer - Chlorpheniramine maleate

Refer - Chlorpheniramine maleate