Drug Interaction:
Interacting drugs - summary
Pipercillin +
Nondepolarizing neuromuscular blockers- Actions of NNBs may be potentiated possibly resulting in profound and severe neuromuscular respiratory depression blockers
Probenecid administered concomittantly prolongs the half-life of pipercillin and tazobactum
When administered simultaneously with high doses of heparin, oral anticoagulants or other drugs that may affect the blood coagulation system or thrombocyte function, coagulation parameters should be tested more frequently and monitored regularly.
Pipercillin when used concomittantly with vecuronium prolongs the neuromuscular blockade of vecuronium. Neuromuscular blockade produced by any of non-depolarizing muscle relaxants could be prolonged in the presence of pipercillin.
Aminoglycoside should be reconstituted and administerd separately as co-ordination can result in substantial inactivation of the glycosides
Laboratory interactions: Pipercillin /tazobactum may result in a false postive reaction for glucose in urine using copper-reduction method. It is recommended that glucose tests based on enzymatic oxidase reactions be used.
Indication:
Infections caused by pipericillin resitant organisms
Appendicitis Peritonitis Soft tissue infection Lower respiratory infections Intra-abdominal infection Urinary tract infection
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Piperacillin + Antibiotic 13-08-1999
Tazobactum IV inj
Adverse Reaction:
Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, hiccups, ulcerative colitis
Contra-Indications:
History of allergic reactions to any of the penicillins, cephalosporons, or beta-lactamase inhibitors
Special Precautions:
Should be administered with caution in pregnancy and lactation
Should be administered with caution in patients with a history of penicillin hypersensitivity or a history of sensitivity to multiple allergens
Periodic assessment of hematopoietic function should be performed especially with prolonged therapy
Pipercillin is a monosodium salt of pipercillin and tazobaactum is a monosodium salt of of tazobactum and contains a total of 2.35 mEq (54mg) of Na per gram of pipercillin in the combination product.
This should be considerd when treating patients requiring restricted salt intake.
Periodic electrolyte determinations should be performed in patients with low potassium reserves, and the possibility of hypokalemia should be kept in mind with patients who have potentially low potassium reserves and who are receiving cytotoxic therapy for diuretics.
As with other semi-synthetic penicillins, pipercillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.
Dosages/ Overdosage Etc:
Indications:
Infections caused by pipericillin resitant organisms
Appendicitis
Peritonitis
Soft tissue infection
Lower respiratory infections
Intra-abdominal infection
Urinary tract infection
Dosage:
Usual recommended dosage is adminstered by IV infusion over 30 min.The usual total daily dose for adults is 12/1.5 g for 7 to 10 days given every 8 hours
Pharmacology/ Pharmacokinetics:
Pharmacology:
Pipercillin acts by inhibiting septum formation and cell wall synthesis. It is active against a variety of gram-postive and gram-negative aerobic and anaerobic bacteria.
Tazobactum is beta lactamase inhibitor in particularly the plasmid mediated enzymes, which commonly cause resistence to penicillins and cephalosporins.
Tazabactum in combination with pipercillin enhances and extends the antibiotic spectrum of pipercillin to include many beta lactamase producing bacteria normally resistent to it and other lactum antibiotics.
Pharmacokinetics:
Pipercillin/Tazobactum is well absorbed following parentral administration, but not if administered orally. It is widely distributed into tissues, body fluids, including intestinal mucosa, gallbladder, skin, lungs, female reproductove tissues, (uterus,ovary) and fallopian tube. Peak plasmaa concentratin are attained immediately after completion of an intravenous infusion.
The plasma half-life of pipercillin and tazobactum ranged from 0.7 to 1.2 hours. Pipercillin is
metabolized in a single pharmacologically inactive metabolite. Both are eliminated via the kidney by glomerular filtration and tubular secretion.
Pipercillin is excreted with 68% of the administerd dose as unchanged drug. Both pipercillin and tazobactum are approximately 30% bound to plasma.
Interaction with Food:
Reports not available
Pregnancy and lactation:
Should be administered with caution in pregnancy and lactation
