Increased irritation may result from concomittant use of potentially irritating topical products such as abrasive soaps, products with pronounced drying effect and those containing alcohol or astringents.

Caution to be excercised while using preparations containing sulfur, resorcinol, or salicylic acid in combination.

If these preparations have been used, it is advisable not to start therapy with until effects of such preparations in the skin have subsided.

Special precautions-

Excessive exposure to sunlight or UV radiation should be avoided.Women of child bearing age should use an effective means of contraception while receiving the drug.The medicine should be kept away from the eyes, lips, nostrils, and mucous membranes

Mild skin irritation with formulations containing 0.03 or 0.1% of the drug.

Erythema, cutaneous dryness, sensations of stinging and burning and pruritus to be expected in 10 to 40% of the cases treated with formulations containing 0.1% of the drug.

Hyperesensitivity

Special precautions:

Excessive exposure to sunlight or UV radiation should be avoided.

Women of child bearing age should use an effective means of contraception while receiving the drug.

The medicine should be kept away from the eyes, lips, nostrils, and mucous membranes

 It should not be applied to cuts, abrasions, scaly or flaky skin, or patches of sunburned skins.

The extremes of winter weather, including high winds and cold tempuratures, can cause extra skin irritations and dryness.

Solution should be discontinued if hypersensitivity to any of the ingredients is noted. Safety and efficacy of drug in children less than than 12 years of age not established.

Indication-

Acne vulgaris

Dosage-

After washing affected areas apply a thin film of adapalene 0.1% once a day before bedtime.

1. Medication is for external use only.

2. Avoid contanct with eyes, lips, angles, of the nose, and mucous membranes.

3. Cleanse area with a mild or soapless cleaner before applying this medication.

4. Moisturizers may be used if necessary , however products containg alpha- hydroxy or glycolic acids should be avoided.

5. This medication should not be applied to cuts, abarasions, eczematous or sunburned skin.

6.Wax epilation should not performed on treated skin due to potential for skin erosions.

7.During early weeks of therapy, an apparent exaccerbatioin of acne may occur. This is due to action of this medication on previuosly unseen lesions and should not be considered a reason to discontinue therapy.

Overal benefits may be seen after 2 weeks of therapy,but 8 weeks are required to beneficial results

Pharmacology:

The drug binds to retionic acid receptors found predominantly in the terminal differentiation of epidermis. It is more active than tretinoin in modulating cellular differentiation. Adapalene inhibits cell proliferation and is similar to that of tretionin. Adapalene is > 3 times more active than tretionin in modulating cell differentiation - in vitro-.

Pharmacokinetics:

The release of adapalene assessed by diffusion through a siliastic membrane was greater from lotion and hydroalcoholic gel formulations than from aqueous gel and cream formiulations, 24 hours after topical application of radiolabelled adapalene to the skin of hairless animal model. Excretion appears to be primarily by the billiary route.

Women of child bearing age should use an effective means of contraception while receiving the drug.