Drug Interaction:
None reported.
Indication:
Scabies
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Permethrine Antilice/Antiscabies March 1995
Adverse Reaction:
Mild transient burning, stinging, pruritus, erythema, tingling,numbness and rash.
Contra-Indications:
Hypersensitivity, lactation, infants less than 2 mths.
Special precautions: Pregnancy, pruritus, oedema, erythema, contact with eyes.
Dosages/ Overdosage Etc:
Indications:
Scabies
Dosage:
Liquid- Throughly massage into the skin from to the soles of the feet. Missed dose-
1. If you miss a dose of this medicine, take it as soon as possible.
2. However, if it is almost time for next dose, skip the missed dose and go back to your regular dosing schedule.
3. Do not double doses.
Other Information:
EVIDENCE BASED MEDICINE (April 2003) Treatment of Scabies Comparative effectiveness of various interventions Beneficial
1. Permethrin - cure rate of about 90% Likely to be beneficial
1. Crotamiton Unknown effectiveness
1. Malathion
2. Benzyl benzoate - cure rate of about 50 percent
3. Oral ivermectin
4. Sulphur compounds Trade-off between benefits and harms
1. Gamma benzene hexachloride (lindane) KEY POINTS
1. One systemic review of mainly small randomised clinical trials has found that topical permethrine and gamma benzene hexachloride has been linked to rare reports of serious side effects
2. There is limited evidence that crotamiton is safe but less effective than permethrine
3. There is insuffcient evidence on the effects of other topical agents (malathion, benzyl benzoate, and sulphur compounds). On the basis of case series, malathion acheived 80% cure rates but its safety has not been established
4. There is insufficient evidence on the effects of oral invercetin. It s known to be safe in adults based on the experience of its use in onchocerciaciasis, but its safety in elderly and children is uncetain.
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
PERMETHRINE - Topical
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
permethrin or synthetic pyrethroids, such as those found in household
insecticides containing permethrin. Also tell your healthcare care
professional if you are allergic to any other substances such as foods.
preservatives or dyes.
2.Pregnancy-
Pyremethrin has not not been studied in pregnant women. However,
this mediction has not shown to cause birth defects or other problems
in animal studies.
3. Breast-feeding-
It is not known whether permethrin passes into breast milk. However,
animal studies have shown that permethrin can cause tumors, Be sure
that you have discussed the risks and benefits with your doctor.
4.Children-
Studies of this medicine has been done only in adult patients and there
is no specific information comparing topical permethrin in children
with use in other age groups.
5.Older adults-
There is no specific information comparing use of topical permethrin
in the elderly with use in other age groups
6. Other medicines-
Tell your doctor if you are using any other prescription or non-prescription
(Over-the counter) OTC medicine that is applied to the scalp.
7. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
especially-
Severe inflammation of the scalp- use of permethrin may make the condition
worse
Pharmacology/ Pharmacokinetics:
Pharmacology: Permethrin is a synthetic pyrenoid active against live ticks, mites and fleas. It acts on the parasite nerve cell membranes to disrupt sodium channel current, resulting in paralysis of the pests.
Pregnancy and lactation:
Use contraindicated. Observe caution
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