Chlorambucil @ - Nitogen mustard- Alkylating agent
Drug Name:Chlorambucil @ - Nitogen mustard- Alkylating agent
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Pharmacology/ Pharmacokinetics
Interaction with Food
Pregnancy and lactation
Drug Interaction:
Alkylating Agents Include-
Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin
Potentiation of other myelosuppressive agents.
Phenylbutazone and warfarin potentiate the effect of Chlorambucil.
Indication:
Alkylating Agents Include-
Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard, Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin
Hodgins disease
Certain forms of non-Hodgkins lynphomas
Chronic lyphocytic leukemia
Adverse Reaction:
Bone marow suppresion.
Careful monitoring of blood count necessary.
Severe interstitial pulmonary fibrosis.
Hepatotoxicity, chromatid and chromosomal damage hence increased incidence of second malignancy. Neurotoxicity.
Reversible progressive lympocytopenia, neutropenia,
GI distrb, hepatotoxicity,
Skin rashes,
Central neurotoxicity including seizures,
Interstitial pneumonia,
Pulmonary fibrosis.
High doses may produce azoospermia and amenorrhoea.
Contra-Indications:
Leucopenia/Thrombocytopenia due to marrow infiltration or prevous cytotoxic herapy. Pregnancy.
Special precautions:
Renal/hepatic dysfunction, fertility, lactation, following radiotherapy.
Regular monitoring of blood counts.
Dosages/ Overdosage Etc:
Indications:
Hodgins disease Certain forms of non-Hodgkins lynphomas Chronic lyphocytic leukemia
Dosage:
Usual dose is 0.1 to 0.02mg/kg/day for 3 to 6 weeks.
Maintenance - do not exceed 0.1mg /kg day.
Patient Information:
Pharmacology/ Pharmacokinetics:
Pharmacology:
Chorambucil is a bifunctional alkylating agent of the nitogen mustard type. It appears to be relatively free of GI effects or other evidence of toxicity apart from its bone marrow depressant action. Chlorambucil interacts with celluar DNA to produce a cytotoxic cross-linkage.
Pharmacokinetics:
Chlorambucil is rapidly and completely absorbed from the GI tract following oral administration. Peak plasma chlorambucil levels are reached in 1 hour., extensive metabolic degradation occurs with 1% unchanged drug recovered in the urine in over 24 hours. The palsma half-life is 60 minutes.
Interaction with Food:
Food reduces peak seum levels.
Take on an empty stomach. Ensure hydration .
Swallow whole. Do not crush /chew
Pregnancy and lactation:
Pregnancy:
No adequate and well controlled studies in pregnant women. Appraise pateints of the potential hazards to the fetus, also advise women of child bearing potential to avoid becoming pregnant.
Lactation:
Not known whether is excreted in breast milk. Excercise caution and weigh potential benefits against the hazards before administration to nursing mothers.
