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Updated On: 27-02-2024

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Mitotane (o,p-DDD) ( * )- @ Antineoplastics

Drug Name:
Mitotane (o,p-DDD) ( * )- @ Antineoplastics

List Of Brands:

LYSODREN *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

Drug Interaction:

Antineuoplastic agents include- Interferon ALFA 2a, Interferon ALFA -2b, Interferon ALFA -n3, Levamisole, Altretamine, Cladribine, Hydroxyurea, Aldesleukin, Paclitaxel, Docetaxel,Tretinion, Procarbazine,Dacarbazine, Gemcitabine, Mitotane, Asparaginase, Pegaspargase,Porfimer Sodium

Interacting drugs- summary

Mitotane +

Corticosteroids- corticosteroids metabolism altered by mitotane, higher doses may be required.

Warfarin- metabolism of warfarin accelrated by the mechanism of hepatic mircosomal enzyme induction, leading to an increase in dosage requirement of warfarin

Indication:

Adrenal cortical carcinoma

Antineuoplastic agents include- Interferon ALFA 2a, Interferon ALFA -2b, Interferon ALFA -n3, Levamisole, Altretamine, Cladribine, Hydroxyurea, Aldesleukin, Paclitaxel, Docetaxel,Tretinion, Procarbazine,Dacarbazine, Gemcitabine, Mitotane, Asparaginase, Pegaspargase,Porfimer Sodium

Adverse Reaction:

Anorexia, nausea,or vomiting, and diarrhea. Depression as manifested by lethargy, Somnolence, Dizziness and vertigo. Transceint skin rashes.

Contra-Indications:

Hypersens to the drug

Special precautions:

Adrenal insufficiency may develop- consider adrenal steroid replacement

Dosages/ Overdosage Etc:

Indication:

Adrenal cortical carcinoma

Dosage:

Start at 2 to 6 g/day in divided doses, 3 or 4 times daily. Increase dose incrementally to 9 to 10g/day.

Patient Information:

MITOTANE -

Ref - USP PDI Vol II 17th Edition (1997)

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

Mitotane. Also tell your healthcare care professional if you are allergic to

any other substances such as foods. preservatives or dyes.

2.Pregnancy-

Mitotane has not been shown to cause problems in humans.

3. Breast-feeding-

Although it is not known whether mitotane passes into breast milk. it has been

reported to cause problems in nursing babies

4.Children-

Although there is no specific information comparing use of mitotane in children

with use in other age groups, this medicine is not expected to cause different

side effects or problems than it does in adults.

5.Older adults-

There is no specific information about the use of mitotane in the elderly.

6. Other medicines-

Tell your doctor if you are using any of the following -

CNS stystem depressants- CNS depressant effects may be increased

7. Other medical problems-

Make sure you tell your doctor if you have any other medical problems

especially-

Infection -

Liver disease - effects may be increased because of slower removal of

mitotane from the body.

Pharmacology/ Pharmacokinetics:

Pharmacology:

Mitotane is an adrenal cytotoxic agent, although it can cause adenal inhibition without cellular destruction. The primary action is on adrenal cortex.

Pharmacokinetics:

Forty percent of mitotane is absorbed. it can be found in most of the body tissues but is primarily stored in fat.Approximately 10% of the drug is excreted in the urine as unidentified water soluble metabolite. Upto 60% is excreted unchanged in the stool.

Pregnancy and lactation:

Pregnancy:

Use only if needed

Lactation:

Use with caution and decide whether to,discontinue the drug or discontinue nursing depending on the importance of the drug to the patient

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.