Goserelin acetate- @- Gonadotropin Hormone analag- (Jun 1980)
Drug Name:
Goserelin acetate- @- Gonadotropin Hormone analag- (Jun 1980)
List Of Brands:
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
Drug/lab interactions: Gosrelin suppresses the pitutary-gonadal system .Therefore, diagnostic tests of pituitary -gonadotropic and gonadal functions conducted during treatment and until resumption of menses may show misleading results
Indication:
Prostatic acne, endometriosis
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Goserelin Acetate For the treatment of 24-04-1996
prostrate cancer,
endometriosis
Patent Expiry Date of drugs (Ref - IDMA Publication)
Chemical Category Manufacturer/ US Patent
Ingredient- Marketer Expiration Date
Goserelin Cancer/Oncology AstraZeneca 27-06-2000
Acetate
Adverse Reaction:
Hot flushes, Sexual dysfunction, Decreased erections, Lower urinary tract symptoms, Lethargy, Pain, Edema, Upper respiratory infection, Rash, Sweating, Anorexia, Achronic obstructive pulmonary disease, Dizziness, Insomnia, Nausea.
Contra-Indications:
Pregnancy, lactation, non diagnosed vaginal bleeding
Special precautions:
Prostatic and breast cancer worsening, hypercalcemia, lipids levels, bone mineral density changes, antibody formation.
Dosages/ Overdosage Etc:
Indications:
Prostatic acncer, endometriosis
Dosage: Monthly (3.6mg) implant- administer SC every 28 days into upper abdominal wall. Local anesthesia may be used before injection
Patient Information:
Ref - USP PDI Vol II 17th Edition (1997)
1.Allergies-
Tell your doctor if you are have ever had any unusual or allergic reaction to
goserilin .
2.Fertility-
Goserilin causes fertility whic may be permanent.If you plan to have children
discuss this with your doctor.
3.Older adults-
This medicine is not expected to cause different side effects or problems in
older people than they do in younger adults.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Goserelin acetate is a synthetic decapeptide analog of luteinizing hormone-releasing hormone. It acts as a potent inhibitor of pituitary gonaddotropin secretion when administerd in biodegradable formulation
Pharmacokinetics:
Peak serum levels are acheived 12 to 15 days after SC administration in males. Goserelin implant is absorbed at a much slower rate initially for the first 8 days, and there is more rapid and continuous absorption for the remainder of the 28 day dosing period.
Pregnancy and lactation:
Pregnancy:
Do not use in women who are or who may become pregnant while receiving the drug.
Lactation:
Discontinue the drug before breast feeding
