Drug Information

Updated On: 18-11-2024

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Thioguanine (TG, Thioguanine) -@ Antimetabolite

Drug Name:
Thioguanine (TG, Thioguanine) -@ Antimetabolite

List Of Brands:

THIOGUANINE *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

Drug Interaction:

None reported.

Indication:

Acute nonlymphocytic leukemias

Adverse Reaction:

Myelosuppression. Nausea, vomiting, anorexia, stomatitis. Intestinal necriosis and perforation in some cases have occured. Hyperuricemia frequent occurance.

Contra-Indications:

Prior resistence to the drug.

Special precautions:

Hepatotoxicity- jaundice ahs occured. Monitor liver function tests -serum transaminase, alkaline phosphatase, bilirubin) at weekly intervals with first beginning of therapy

Dosages/ Overdosage Etc:

Indications: Acute nonlymphocytic leukemias

Dosage: Individualise dose. Initial dosage for children and adults- 2mg/kg/day orally. If after 4 weeks there is no clinical improvement and no leukocyte or platelet depression, the dosage may be increased to 3mg/kg/day.

Patient Information:

1. Notify physician if fever chills, nausea, vomiting sore throat, unusual bleeding

or bruising, yellow disclouration of skin or eyes,swelling of the feet or legs or

abdominal pain or joint or flank pain occurs.

2. May cause diarhea, fever, and wewakness. Notify physician if these become

pronounced.

3. Drink plenty of fluid while taking this drug

4. Contraceptive measurers are neccessary during therapy for men and women.

Ref - USP PDI Vol II 17th Edition (1997)

THIOGUANINE - SYSTEMIC

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

Thioguanine..

2.Pregnancy-

Tell your doctor if you are pregnant or intend to have children. There is a

chance that this medicine may cause birth defects if either the male or

female is taking it at the time of conception or if it is taken during pregnancy.

In addition many cancer medicines may cause strelity which may be

permanent.

Tell your doctor right away if you think you are pregnant while receiving this

medicine.

3. Breast-feeding-

Tell your doctor if you are breast feeding or if you intend to breast feed during

treatment with this medicine. Because thioguanine may cause serious side

effects, breast feeding is not generally recommended while you are taking it.

4.Children-

Although there is no specific information comparing use of thioguanine

in children with use in other age groups, this medicine is not expected

to cause different side effects or problems than it does in adults.

5.Older adults-

There is no specific information comparing use of thioguanine in the

elderly with use in other age groups.

6. Other medicines-

When you taking this medicine it is important that you tell your doctor

if you are using any prescription medicine which may cause serious

adverse effects

7. Other medical problems-

The presence of other medical problems may affect the use of thioguanine.

Make sure you tell your doctor if you have any other medical problems.

Pharmacology/ Pharmacokinetics:

Pharmacology:

Thioguanine an analog of the nucleic acid constituent guanine, is closely related structurally and functionally to 6-mercaptopurine. Thioguanine compete with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is converted to 6-thioguanylic acid(TGMP). TMCP interferes at several points with the synthesis of glutamin nuclotides.

Pregnancy and lactation:

Pregnancy:

Advise women of child bearing age to avoid pregnancy

Lactation:

Excercise caution and decide whether to discontinue the drug or discontinue nursing depending on the importance of the drug to the mother.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.