Drug Information

Updated On: 18-11-2024

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Mitomycin-C ( * ) - @- Antibiotic

Drug Name:
Mitomycin-C ( * ) - @- Antibiotic

List Of Brands:

ALMITO
MITOCIN
MITOMYCIN-C INJ

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Interacting drugs- summary

+ Mitomycin

Vinblastine

Acute shortness of breath and severe bronchospasm have occurred

following use of vinca alkaloids in patients who had previousyt

received mitomycin. Onset may be within minutes or several hours

after the vinca alkaloid is injected and may occur up to 2 weeks after the

dose of mitomycin

Adriamycin

Potentiates adriamycin induced cardiotoxicity.

Doxirubin

Enhancement of pulmonary damage by nitrosoureas and doxirubicin.

Barbiturates/ Cimetidine

Barbiturates and cimetidine alter levels and its effect on host and

tumor metabolism

5-Flurocil

Synergy with 5-flurocil

Cytotoxicity

Enhances cytotoxic effect of radiation especially in presence of hypoxia.

Indication:

Adenocarcinoma of stomach or pancreas, with other chemotherapeutic agents.

Adverse Reaction:

Micro-angiopathic haemolytic anaemia and renal toxicity. Delayed cumulative bone marrow supression, profound leucopenia and thrombocytopenia.

Renal damage, pulmonary reactions, G.I.toxicity, alopecia, fever.

Contra-Indications:

Bone marrow depression and haemorrhagic tendencies,neonates, pregnancy.

Special precautions:

Leucopenia, lympocytopenia and ulceration of the mouth. Leakage outside blood vessels causes necrosis. Never to be given i.m. or s.c. Monitor renal function.

Dosages/ Overdosage Etc:

Indications:

Adenocarcinoma of stomach or pancreas, with other chemotherapeutic agents

. Dosage:

Give IV only. Use 20mg/sqm IV as a single dose at 6 or 8 weeks intervals.

Patient Information:

Ref - USP PDI Vol II 17th Edition (1997)

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

Minoxidil. Also tell your healthcare care professional if you are allergic to

any other substances such as foods. preservatives or dyes.

2.Pregnancy-

Minoxidil has not been studied in pregnant women. However, there are

reports of babies born with thick or dark hair on their bodies after the

mothers took minoxidil during their pregnancy. Discuss this possible

effect with your doctor.

3. Breast-feeding-

Although minoxidil passes into breast milk, it has been reported to cause

problems in nursing babies.

4.Children-

Although there is no specific information comparing use of minoxidil

in children with use in other age groups, this medicine is not expected

to cause different side effects or problems than it does in adults.

5.Older adults-

Elderly patients are more sensitive to the effects of minoxidil, In addition,

Minoxidil may reduce the tolerance to cold temperature in elderly patients.

6. Other medicines-

Tell your doctor if you are using any of the following -

Guanethidine or

Nitrates -severe lowered blood pressure may occur

7. Other medical problems-

Make sure you tell your doctor if you have any other medical problems

especially-

Angina -minoxidil may make the condition worse

Heart attack or stroke - lowering of blood pressure may make problems

resulting from heart attack or stroke worse.

Heart or blood vessel disease- minoxidil can cause fluid buildup,

which can cause problems

Kidney disease- effects may be increased bcause of slower removal

from the body

Pheochromocytoma- minoxidil may cause the tumor to be more active.

Pharmacology/ Pharmacokinetics:

Pharmacology:

Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA).

Pharmacokinetics:

Clearance is effected primarily by hepatic metabolism. About 10% of a dose is excreted unchanged in the urine.

Interaction with Food:

Not available

Pregnancy and lactation:

Pregnancy: Safety for use on pregnant women is not established.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.