Vincristine ( * ) - @-Mitotic inhibitors
Drug Name:Vincristine ( * ) - @-Mitotic inhibitors
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Other Information
Patient Information
Pharmacology/ Pharmacokinetics
Interaction with Food
Pregnancy and lactation
Drug Interaction:
Indication:
Acute leukemia
Mitotic inhibitors include- Etoposide, Vincristine, Vinblastine, Teniposide, Vinorelbine tartarate
Adverse Reaction:
Myleosupression. Neuromuscular toxicity, Hyperuremia,brochospasm, azosperma, Menorrhoea, alopecia, Leucopenia, pain,
Constipation, Paralytic ileus, Urinary dysfunction.
Contra-Indications:
Patients with a form of Charcot-Marie tooth syndrome.
Pregnancy.
Special precautions:
Acute uric acid neuropathy may occur. Care in patients with leucopenia or a complicating infection.
Cytocristin should not be given to patients receiving radiation therapy through parts include liver. Pregnancy, lactation.
Dosages/ Overdosage Etc:
Indications: Acute leukemia
Dosage: Cautiously calculate and administer dose.
Over dosage may be serious or fatal
. Adults- 1.4 mg/sqm. For children weighing less than 10 kg or a body surface area less than 1sqm., give 0.05 mg/kg once a week.
Other Information:
Hyponatremia-
Hyponatremia indicates that the body fluids are diluted by an excess of water relative to total solute. Most types of hyponatremia can be considered to result from defective urinary dilutuion . Normal watervdilutiuon requires three factors
1. Secretion of ADH must be suppressed.
2. Sufficient sodium and water must reach the diluting sites of the nephron, in the asending limb of Henles loop and the distal convoluted tubule
3. Therse nephron segments must function normally , reabsorbing sodium while remaing impermeable to water.
Drugs causing adverse reactions- Dilutional
1. Vincristine
2. Cyclophosphamide
3. Chlorpropamide
4. Diuretics
Drugs causing adverse reactions- Salt wasting
1. Diuretics
2. Corticosteroids- withdrawal
3. Enema 4. Mannitol
Patient Information:
Pharmacology/ Pharmacokinetics:
Pharmacology:
Vincristine sulphate is an alkaloid from the periwinkle. Mode of action is unknown. In vitro, it arrests mitotic divison at metaphase. Antineoplastic effects are related to interference with intracellular tubulin function.
Pharmacokinetics:
Within 15 to 30 minutes following IV admin. more than 90% of the drug is distributed from blood to tissue where it remains tightly, but not irreversibly bound. The liver is the major excretory organ more than 80% of a dose appears in feces and 10 to 20% in the urine.
Interaction with Food:
Not applicable
Pregnancy and lactation:
Use contraindicated. Observe caution
