Reports not available

Metastatic islet cell carcinoma of the pancreas

Nausea and vomiting, diarrhea. Chemical liver dysfunction occurs in 25% of the patients. Hematological toxicity has been rare, most often involoving mild decreases in hemotocrit.

Mild to moderate abnormalities of glucose tolerance have generally been reversible, but insulin shock with hypoglycemia has occured. Confusion,lethargy and depression have occurred

None reported

Special precautions:

Monitoring-closely monitor for evidence of renal, hepatic and hematopoietic toxicity . Perform complete blod counts and liver function tests at least weekly.

Metastatic islet cell carcinoma of the pancreas

Daily schedule- 500mg/m2 of body surface area BSA for 5 concesutive days every 6 weeks until maximum benefit or until treatment limiting toxicity is observed

Dosage increases are not recommended

Pharmacology: Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. The biochemical examination leading to mammalian cell death has not been established.

Pharmacokinetics: After IV injection, unchanged drug is rapidly cleared from the plasma(half-life 35 minutes). Most excretion is completed in 24 hrs.

Pregnancy: Use during only if the potential benefit outweighs the potential risks

Lactation: Discontinue nursing in patients receiving streptozocin