Potentiation of other myleosupressive drugs.

Anti-emetics,sedative administered prior to mustine reduce nausea and vomiting.

Reduces absorption of many drugs given orally.

Myleosuppression. Bone marrow depression, Severe nausea and vomiting, Tinnitus, vertigo, Deafness, Maculopapar rashes, Temporary or permanent inhibition of fertility, Headache, Hallucinations, Convulsions, Paraplegia and tremors, Jaundice(occasionally) Topical application: High incidence of hypersentivity.

Severe leucopenia/thrombocytopenia, anaemia, co-existing infectious granuloma, pregnancy, I/M injection.

Special precautions:

Frequent blood counts. Extravasation during injection causes severe local reaction and tissue necrosis.

Peripheral neuropathy- ----------------------------- Drugs causing adverse reactions- ( 388 ) ---------------------------------------------------------- 1. Isoniazid 2. Hydralazine 3. Nitrofurantoin 4. Vincristine 5. Mustine 6. Streptomycin 7. Polymixin, Colistin 8. Clioquinol 9. Phenelzine 10. Tricyclic antidepressants 11. Chlramphenicol 12. Procarbazine 13. Ethambutol 14. Ethionamide 15. Glurtethimide 16. Democycline 17. Nalidixic acid 18. Tolbutamide 19. Chlorpropamide 20. Methysergide 21. Phenytoin