Drug Information

Updated On: 27-02-2024

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Azathioprine ( ** ) - @ Immunosuppressive drug- (Dec 2008)

Drug Name:
Azathioprine ( ** ) - @ Immunosuppressive drug- (Dec 2008)

List Of Brands:

AZOPRINE
AZORAN
IMURAN

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Immunosuppressant drugs include-

Azathioprine, Tacrolimus (FK 506 ), Mycophenolate Mofetil, Cyclosporine, Muromonab -CD3,

Interacting drugs-summary

Azathropine +

ACE inhib

concurrent use may induce severe leukopenia

Allopurinol

allopurinol may increase the pharmacologic and toxic effects of azathioprine

Methotrexate

plasma levels of the 6-MP metabolite may be increased

+ Azathiprine

Anticaogulants

azathioprine may decrease the action of the anticoagul

Cyclosporine

cyclosporine plasma levels may be decreased

Non deplorarising neuromuscular blockers

pharmacologic actions of the neuromuscular blockers may be decreased or reversed

Indication:

U.S FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08

Drug name Indication Date of Approval

264. Azathioprine 25mg tablets 19-12-08

(Addl.stgth)

Immunosuppressant drugs include-

Azathioprine, Tacrolimus (FK 506 ), Mycophenolate Mofetil, Cyclosporine, Muromonab -CD3,

Renal hemotransplantation, adjunct for prevention of rejection in renal hemotransplantation, rheumatoid arthiritis.

New drugs approved For Marketing by Drug Controller General of India(DCGI )

during the period January 1988 to November 2014

(Ref- IDMA Annual Publication 2015)

Name of Drug Indication Date of Approval

Azithioprine 25mg tablets 19-12-2008

( Addl.stgth)

Adverse Reaction:

Myleosuppression,mutagenicity and carcinogenicity.

Generally reversible bone marrow depression (esp leucopenia, thrombocytopenia) anorexia, Nausea,diarrhoea, Secondary infections,

Pancreatitis, Hepatotoxicity, Rash, alopecia.

Contra-Indications:

Immunosuppression,hypersens,previous treatment with alkylating agents.

Special precautions:

Leucopenia, thrombocytopenia, hepatic impairment, regular blood counts, pregnancy.

Dosages/ Overdosage Etc:

Indications:

Renal hemotransplantation, adjunct for prevention of rejection in renal hemotransplantation, rheumatoid arthiritis.

Dosage:

Initial dose usually 3 to 5mg/kg/day given as a single dose.

Rheumatoid arthiritis - initial dose Img/kg(50 to 100mg) given as a single dose.

Maximum dose 2.5mg/kg/day.

Other Information:

Pancreatitis

Drugs causing adverse Reactions-

1. Corticostetoids

2. Thiazides

3. Azathioprine

4. Oral contraceptives

5. Sulfonamides

6. Opiates

7. Furosemide

8. Ethacrynic acid

Patient Information:

1. If GI upset occurs, administer in divided doses or take with food.

2. Notify physician if any of the following occurs; unusual bleeding, or bruising, fever, sore throat, mouth sores, signs of infection, abdominal pain, pale stools, or darkened urine.

3. Inform patients of the necessity of periodic blood counts.

4. May cause nausea, vomiting, skin rash, fever, arthalgias, and diarrhea. Inform physician if these become bothersome.

5. Avoid patients of the potential risks of therapy during pregnancy and breast feeding.

6.Allergies-

Tell your doctor if you have ever had any unusual oe allergic reaction to azathioprine.

Aso tell your doctor if you are allergic to any other substances, such as foods,

presrvatives, or dyes

7.Pregnancy-

Use of azathipoprine is not recommended during pregnancy. It may cause side effects

if either the male or the female is using it at any time of conception. The use of birth

control methods is recommended. If you have questions about this check with your

doctor.

8.Breast -feeding-

Azothioprine passes into breast milk. Because this medicine may cause serious side

effects, breast-feeding is not generally recommended

9.Children-

This medicine has not been tested in children and in effective doses, has not been

shown to cause different side effects or problems than it does in adults.

10.Elderly-

Many medicines have not been studied specifically in older people. Therefore

it may not be known whether they work excactly the same way they do in younger

adults. Although there is no specific information comparing use of azothioprine

in the elderly with use in other age groups, this medicine is not expected to cause

different side effects than it does in younger adults.

11.Other medicines -

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur. in such

cases your doctor may want to change the dose, or other precautions may be necessary.

When you taking or receiving azathioprine it is especially important that your doctor

know if you taking any of the following-

Allopurinol (eg.Zyloprim ) - may interfere with removal of azothiprine from the body,

the effects of azathioprine ( including toxicity) may be increased

Chlorambucil (eg.Leukeran) or

Corticosteroids ( cortisone -like medicine) or

Cyclophosphamide (eg.Cytoxan ) or

Cyclosporine (eg.Sandimmune) or

Mercaptopurine (eg. Purinethol) or

Muromonab -CD3- (monoclonal antibody) (eg. Orthoclone OKT3)- there may be

increased risk of infection and cancer because azothioprine reduces the bodys

ability to fight them

12.Other medical problems-

The presence of other medical problems may affect the use of azothiprine. Make sure that you tell your doctor if you have any other medical problems especially-

Chickenpox (including recent exposure) or

Herpes zoster (shingles) - risk of severe disease affecting other parts of the body

Gout- Allopurinol (used to treat Gout) may increase wanted and unwanted effects of

azathioprine

Infection - Azathioprin decrease your bodys ability to fight infection

Kidney disease- or

Liver disease - effects of azothioprin may be increased because of slower removal

from the body

Pancreatitis- (inflammation of the pancreas) azathioprine can cause pancreatitis

Pharmacology/ Pharmacokinetics:

Pharmacology:

Azathioprine is an imidazoyl derivative of 6-mercaptopurine(6-MP) has many biological effects similar to those of the parent compound.

Pharmacokinetics:

Azathioprine is well absorbed following oral admin. Maximum serum radioactivity occurs at 1 to 2 hours after oral radioactive azathioprine and decays with a half-life of 5 hours.

Interaction with Food:

Preferably taken with or after meals to reduce GI discomfort

Pregnancy and lactation:

Pregnancy:

Azathioprine can cause fetal harm when administered to pregnant women. Excercise caution and whenever possible avoid using the drug on pregnant patients.

Lactation:

Use in nursing mothers not recommended.

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.