Mutually increased levels effects when used with drugs extensively metabolised by CYP3A Reduced levels/efects of methadone

Skin rash, nausea,vomiting, headache, abnormal LFT, fatigue, diarrhoea abdominal pain severe & life threatening hepatotoxic and skin reactions

Hypersenstivity Lactation Severe hepatic impairment

Special precaution-

Pregnancy- interrupt treatment if severe hepatotoxicity or life threatening skin reactions develop. Renal or hepatic insufficiency Monitor liver function periodically

Dosage-

combined 200mg once daily for 1st 14 days increase to 200mg bid if rash does not develop interupting treatment for > 7 days, necessiciate reintroduction at lower dose for 1st 14 days

Child- combined 2mth - 8yr- 4mg/kg once daily for 1st 14days increase to 7mg/kg bid if no rash is present 8-16yr- 4mg/kg once daily for 14 days followed by 4mg/kg bid max- 400mg daily,interupting for > 7days necissiciate reintroduction at a lower dose for the 1st 14 days

Use contraindicated. Observe caution