None reported

Cyanide poisoning

None reported

Not reported

Special precautions-

Warnings-

Pregnancy-

Use only when needed and when the potential benefits outweigh the potential hazards to the fetus.

Indication:

Cyanide poisoning

Dosage:

Adults- 12.5g IV over 10 m inutes, whether used alone or in combination with other cyanide antidotes

Children-7g/m2 , maximum dose is 12.5g

Pharmacology:

The primary mechanism of cyanide detoxification involves conversion of cyanide to the relatively nontoxic thiocyanate ion. This reaction involves the enzyme rhodanase (tuocyasulfate cyanide sulfurtransferase) found in many body tissues, but with major activity in the liver.

Pharmacokinetics:

The biological half-life is 0.65 hrs.

Pregnancy:

Use with caution, only if required