Anticholinergic toxicity- reverse toxic effects of CNS effects

Pregnancy- Use only if clearly needed and potential benefitsoutweigh hazards to the fetus. Lactation- Safety for usehas not been established. Children- Reserve for life-threatening situations only.

None reported

Nausea, vomiting, salivation, bradycardia and convulsions

Asthma, gangrene, diabetes, cardiovascular disease, GI or GU obstruction. Special precautions: Benzyl alcohol contained in this product as a preservative, has been associated with a fatal - gasping syndrome- in premature infants. Sulfite sensitivity- the product contains sulfites that may cause allergic-type reactions. Warnings- Discontinue drug- if symptoms of excessive salivation or emesis ,frequent urinnation, or diarrhea occur. If excessive sweating or nausea occurs, reduce dosage. Administration rate- rapid administration can cause bradycardia, hypersalivation (leading to respiratory difficulties and seizures. Hypersensitivity- because of the posibility of hypersentivity, atropine sufate should be available as an antagonist and antidote for phytpostigmine. Pregnancy- use only if clearly needed and potential benefitsoutweigh hazards to the fetus. Lactation- safety for usehas not been established. Children- reserve for life-threatening situations only.

Indications: Anticholinergic toxicity- reverse toxic effects of CNS effects Dosage: Anticholinergic toxicity- 2mg Im or IV .Administer IV slowly.

Pharmacology: The action of acetylcholine is transcient because of hydrolysis by acetylcholinesterase. Physiostigmine a reversible anticholineterase drug, increases the acetylcholine at the site of cholinergic transmission and prolongs and exaggerates the effects of acetylcholine. Pharmacokinetics: Readily absorbed and crosses the blood brain barrier following IM or IV admin.