Leucovorin ( * )Antidotes-Folic acid antagonist

Drug Name:
Leucovorin ( * )Antidotes-Folic acid antagonist

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

   

Drug Interaction:

Interacting drugs- summary

Leucovarin + Anticonvulsants decrease  folic acid in large amounts counteract the antiepileptic effect of phenobarbital, phenytoin and primidone and increase the frequency of seizures in susceptible children.

 Consider the possibility when using these drugs concomittantly

5-Fluorouracil -  leucovorin may enhance the toxicity of 5-FU 

Methotrexate-  small quantites of systemically administered leucovorin enter the CSF primarily as 5-methyltertrahydrofolate and remain 1 to 3 orders of magnitude lower than the usual MTX concentrations following intrathecal administration.

However, high doses of leucovorin may reduce the efficacy of intrathecally administerd MTX 

Reduces methoxtrexate toxicity. Enhances cytotoxic effect of fluorocil. Should not be co-administered with a folic acid antagonist.