Drug Information

Updated On: 27-02-2024

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Dextrothyroxine sodium -@Antihyperlipermic

Drug Name:
Dextrothyroxine sodium -@Antihyperlipermic

List Of Brands:

CHOLOXIN *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

Drug Interaction:

Dextrothyroxine +Anticoagulants incr May increase the anticoagulant efect of warfarin or anisindione The risk of bleeding may be increased. The mechanism of action is inknown or complicated. Reduce the dosage of anticoagulants while initiating therapy.

Beta-adrenegic blockers- pharmacologic effects may be decreased Cholestyramine may decrease the G I absorption of dextrothyroxine Digitalis glycosides- therapeutic effects of digitalis may be decreased.

Insulin or sulfonylureas- dextrothyroxine in diabetic patients can increase blood sugar levels. Thyroid hormone- consider dosage when used concomittantly with dextrothyroximine Tricyclic antidepressants- concurrent use may produce CNS stimulation, nervousness, tachycardia and other cardiac arrhythmias.

Indication:

Antihyperlipermic agent

Adverse Reaction:

Angina pectoris, arrthythmias. Insomnia, nervousness, tremors, headache, tinnitis, dizziness. Dyspepsia, nausea, vomiting, constipation, diarrhea. decrease in appetite.

Contra-Indications:

Euthyroid patients. Pregnancy and lactation

Special precautions:

Serum levels- increased serum thyroxine. Tetrazine sensitivity

Dosages/ Overdosage Etc:

Antihyperlipermic agent

Dosage:

Adults- initial - 1 to 2mg.day. increase by 1 to 2mg at intervals of not less than 1 month to a max of 4 to 8mg daily. Maitenace dose 4 to 8mg daily.

Children- initial dose- 0.05mg/kg/day

Other Information:

Patient Information:

Dextrothyroxine - Systemic

1.Notify physicain of chest pain, palpitations, sweating, diarrhea, headache,

or skin rash.

2.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

dextrotyroxine. Also tell your healthcare care professional if you are allergic

to any other substances such as foods. preservatives or dyes.

3.Diet-

Before prescribing medicine for your condition, your doctor will probably

try to control your condition by prescribing a special diet to you. Such a diet

may be low in fats,sugars,and/or cholesterol. Many people are able to

control their condition by carefully following their doctors orders for proper

diet and excercise.

Medicine is prescribed only when additional help is needed and is effective

only when a schedule of diet and excercise is followed.

Also this medicine is less effective if you are greatly overweight. It is important

for you to go on a reducing diet. However, check with your doctor before going

on a diet.

Make sure your doctor knows if you are on any special diet , such as low sodium

or low sugar diet.

3.Pregnancy-

Dextrothyroxine has not been studied in pregnant women. However,studies

in animals have not shown that dextrothyroxine causes birth defects or other

problems. Before taking this medicine make sure that your doctor knows

if you pregnant or if you become pregnant.

4. Breast-feeding-

It is not known whether dextrothyroxine passes into breast milk. Although most

medicines pass into breast milk in small amounts,many of them may be used

safely while breast-feeding. Mothers who are taking this medicine and who wish

to breast feed should discuss this with their doctor.

5.Children-

There is no specific information comparing use of dextrothyroxine in children

with use in other age groups. However, use is not recommended in children

under 2 years of age since cholesterol is needed for normal development.

6.Older adults-

Side effects are more likely to occur in the elderly, who are usually more

sensitive to the effects of dextrothyroxine

7. Other medicines-

Although certain medicines should not be used together at all, in other cases two

different medicines may be used together even if an interaction might occur.

In such cases your doctor may want to change the dose, or other precautions

may be necessary.

When you are taking dextrothyroxine it is especially important that your

doctor know if you are taking any of the following

Antocoaglants- the effects of anticoagulant may be altered , a change of

dosage of the anticoagulant may be necessary

Cholestyramine or

Colestipol - the effects of dextrothyromine may decrease , these two medicines

should be taken atleast 4 to 5 hours before or after dextrothyroxine

8. Other medical problems-

The presence of other medical problems may affect the use of dextrothyroxine.

Make sure you tell your doctor if you have any other medical problems

especially-

Diabetes- blood sugar levels may be increased

Heart or blood vessel disease or

Overactive thyroid - dextrothyroxine may these conditions worse

Kidney disease- higher blood vessels of dextrothyroxine may result

in increase the chance of side effects

Liver disease- may lead to an increase in cholesterol blood levels

Underactive thyroid- there may an increased sensitivity to the effects

of dextrothyroxine

Pharmacology/ Pharmacokinetics:

Pharmacology:

Dextrothyroxine sodium stimulates the liver to increase catabolism and excretion of cholestro and degradation products via the the biliary route into the feces.

Interaction with Food:

Pregnancy and lactation:

Pregnancy:

Conraindicated in pregnancy

Lactation:

Contraindicated in nursing mothers

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