CNS depressants- increase CNS depression produced by propofol.

Induction or maintenance of anesthesia 

Amorous behaviour, hypotonia, neuropathy, opishotonus. Asthenia, myocardial ischemia. Awareness, extremities pain, fever, increased drug effect, neck rigidity/stiffness, chest/trunk pain

When general anesthesia or sedation are contraindicated; hypersensitivity to propofol or components of the product.

Special precaution:

Special risk patients- use a lower induction dose.Epilepsy, occurance of transcient local pain. Hyperlipidermia.

Indication: Induction or maintenance of anesthesia

Dosage: Individualise dose

Performance of activites requiring mental alertness, cordination or physical dexterity may be impaired for some time after general anesthesia or sedation.

Pharmacology: Propofol is an IV sedative agent for induction and maintenance of anesthesia or sedation.

Pharmacokinetics: Profofol is chiefly eliminated by hepatic conjugation into inactive metabolite which are excreted by the kidney.

Pregnancy: Use during pregnancy only when needed

Lactation: Not recommended for use in nursing mothers.