Reports not available

Asthma Chronic obstructive pulmonary disease (COPD) Intestinal Lung disease Dry cough Nocturnal cough Postoperative Cough

No objective side efects (liver and renal function, hamopoietic organs ) observed. Neither allergy symptoms nor dependence were found. Gastrointestinal complaints (gastric pains, tendency to constipation occured in about 10% of the cases, but these could be managed by diet. Slight laxatives were rarely necessary. At higher dose levels the patients occassionally experienced slight sedative effect or tiredness. It should be empasised that both sedative and tiredness occured at higher therapeutic dose levels only and ceased spontaneously within few hours after administration.

Reports not available

Indications

Asthma

Dosage-

Below 12 years- 8mg/kg/day- TID above 12 years- 200mg TID Maximum therapeutic dose that can be given in a day is 1600mg

Pharmacology- Prenoxdiazine hydrochloride has a unique two-way action- - unique desensitizing action on stretch receptors ( peripheral antitissue action ) - significant -bronchospasmolytic - action ( direct smooth muscle relaxant effect) - improves Peak Expiratory Flow Rate - Facilitates Expectoration Phamacokinetics- Peak blood levels are attained at 30- 60 minutes after ingestion. The drug binds to plasma proteins without specificity. Duration of action lasts for 6 to 7 hours A mojor portion of the ingested drug is metabolised in the liver and only one third is excreted unaltered. It is excreted in the feces and urine in 24 hours, 93% of the drug is removed from the body, 56% is excreted in the urine and 22.9% in the stools.