Interacting drugs - summary

Colistin sulphate+

Colistin sulpate  and sodium colimethate + Pancuronium
  Parentral/intraperitoneal administration of high doses of  antibiotics produce neuromuscular block on its own. If these    agents are used preoperatively or in conjunction with pancuronium  during surgery, unexpected  prolongation of neuromuscular block
 is a possibility 

Colistin and sodium  colisthemate + Vecuronium
 parentral/intraperitoneal admininistration of  of high doses of certain antibiotics  may intensify or produce neuromuscular blockade  on their own. If these are newly   introduced are used with vercuronium    during surgery, consider the possibilty of unexpected prolongation    of neuromuscular block
 
Colistin   Colisthemate + Percuronium
Parentral/Peritoneal administration of high doses of cetain antibitotics may intensify or cause neuromuscular blockade on their own. If these or  or newly introduced antibiotics are used with pipercuronium during surgery,  consider prolongation of neuromuscular block, a possiblity.
                

Diarrhoea in infants and children. Gastroenteritis due to shigella organisms..

Acute tubular necrosis,neurotoxicity.

The neuromuscular blockade is potentially fatal,when associated with use of curariform muscle relaxants,hypocalcaemia and aminoglycosides.

Superinfection,renal damage,

GI disturbances,visual & speech disturbances,dizziness,nausea, vomiting,confusion,peripheral neuropathy,respiratory insufficiency & muscle weakness.

Hypersensitivity,Anura,Surgery.

Special precautions:

Preexisting renal impairment,curariform muscle relaxants.

Indications:

Diarrhoea in infants and children. Gastroenteritis due to shigella organisms..

Dosage:

Usual dosage is 5 to 15mg/kg/day given in 3 divided doses.

Assess renal function prior to initiation of therapy.

Tubular necrosis-

 Drugs causing adverse reactions- 

1. Ampotericin B

2. Aminoglycosides

3. Polymixin

4. Cephaloridine

5. Tetracycline

6. Colistin

7. Sulfonamides

8. Radioiodinated contrast media

9. Methoxyflurane

Pharmacokinetics:

Colistin sulfate is not significantly absorbed into the systematic circulation.

Not applicable