Rifampicin

Other CYP3A4 Inducers eg phenytoin, carbamazepine, barbiturates,St Johns Wart, itraconazole,

Other CYPA4 inhibitors eg. ketoconazole, clotrimazole, ritonvir

Drugs that increase gastric pH eg, H2 blockers, proton pump inhibitors metoprolol,

Other drugs metabolised by CYP2D6

May exacerbate neutropenia with vinorelbine

Metastatic non-small cell lung cancer

Hepatic disturbances GI upset, Rash, dry skin, Acne, nail disorder Asthenia, alopecia Interstitial lung disease Peripheral oedema Increased incidence of tumor haemorrhage Dyspnoea Stomatitis

Monitor  LFT    Pregnancy    Lactation

No advantage over methotrexate in head and neck cancers

Suspend if symptoms of intestinal lung disease occur (eg. dyspnoea, cough, fever ), discontinue if confirmed and treat

Pulmonary fibrosis may increase interstital lung disease

Indication-

Metastatic non-small cell lung cancer

Dosage-

250mg once daily

Geftinib-

1. Advice patients to seek medical advice promptly if they develop - severe or persistent
diarrhea, nausea, anorexia, or vomiting as these are sometines associated with dehydration

2. Advice patient to inform their doctor, if they notice any onset or worsening of pulmonary
symptoms eg shortness of breath, or cough , an eye irritation or any other symptoms

3. Advice women of child bearing potential to avoid becoming pregnant

Use contraindicated. Observe caution